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Triumeq vs. Juluca

Reviewed on 3/18/2021

Are Triumeq and Juluca the Same Thing?

Triumeq (abacavir, dolutegravir, and lamivudine) and Juluca (dolutegravir and rilpivirine) are combinations of an integrase strand transfer inhibitor (INSTI) and HIV-1 nucleoside analog reverse transcriptase inhibitors (NRTIs) used to treat human immunodeficiency virus type 1 (HIV1) infection.

Side effects of Triumeq and Juluca that are similar include headache and diarrhea.

Side effects of Triumeq that are different from Juluca include insomnia, fatigue, nausea, vomiting, fever, loss of appetite, low energy, nightmares or abnormal dreams, abnormal body fat distribution, numbness and tingling, hypersensitivity reactions (fever, rash, shortness of breath, cough, or sore throat), joint pain or swelling, muscle pain, extremity swelling, depression, dizziness, and spinning sensation (vertigo).

Both Triumeq and Juluca may interact with other medicines to treat HIV or AIDS, dofetilide, antacids or laxatives that contain aluminum or magnesium (Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids, and others), sucralfate, buffered medicines, vitamin or mineral supplements that contain calcium or iron, St. John's wort, and medicines that contain metformin.

Triumeq may also interact with dalfampridine.

Juluca may also interact with anticonvulsants, antimycobacterials, glucocorticoids, H2-receptor antagonists, macrolide or ketolide antibiotics, narcotic analgesics, and proton pump inhibitors (PPIs).

What Are Possible Side Effects of Triumeq?

Common side effects of Triumeq include:

  • insomnia,
  • headache,
  • fatigue,
  • diarrhea,
  • nausea,
  • vomiting,
  • fever,
  • loss of appetite,
  • low energy,
  • nightmares or abnormal dreams,
  • abnormal body fat distribution,
  • numbness and tingling,
  • hypersensitivity reactions (fever, rash, shortness of breath, cough, or sore throat),
  • joint pain or swelling,
  • muscle pain,
  • extremity swelling,
  • depression,
  • dizziness, and
  • spinning sensation (vertigo).

What Are Possible Side Effects of Juluca?

Common side effects of Juluca include:

  • diarrhea and
  • headache.
  • other antiretroviral medications,
  • dofetilide,
  • metformin,
  • antacids,
  • anticonvulsants,
  • antimycobacterials,
  • glucocorticoids,
  • H2-receptor antagonists,
  • St John's wort,
  • macrolide or ketolide antibiotics,
  • cation-containing products or laxatives,
  • sucralfate,
  • buffered medications,
  • narcotic analgesics,
  • oral calcium and iron supplements (including multivitamins containing calcium or iron),
  • and proton pump inhibitors (PPIs).

QUESTION

What is HIV? See Answer

What Is Triumeq?

Triumeq may interact with dofetilide and other drugs. Tell your doctor all medications and supplements you use.

What Is Juluca?

Juluca (dolutegravir and rilpivirine) is a combination of a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) and an HIV-1non-nucleoside reverse transcriptase inhibitor (NNRTI) indicated as a complete regimen for the treatment of HIV-1 infection in adults to replace the current antiretroviral regimen in those who are virologically suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen for at least 6months with no history of treatment failure and no known substitutions associated with resistance to the individual components of Juluca.

What Drugs Interact With Triumeq?

Triumeq may interact with dexamethasone, imatinib, isoniazid, nefazodone, St. John's wort, antibiotics, antifungals, barbiturates, heart or blood pressure medications, HIV/AIDS medicines, medicines to treat narcolepsy, medications to treat osteoporosis or Paget's disease of bone, seizure medications, or grapefruit and grapefruit juice. Tell your doctor all medications and supplements you use.

What Drugs Interact With Juluca?

Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Juluca; it is unknown how it would affect a fetus. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to Juluca during pregnancy. It is unknown if Juluca passes into breast milk, however, breastfeeding is not recommended due to the potential for HIV transmission.

How Should Triumeq be Taken?

The adult dose of Triumeq is one tablet daily.

How Should Juluca Be Taken?

The dose of Juluca is one tablet taken orally once daily with a meal.

SLIDESHOW

A Timeline of the HIV/AIDS Pandemic See Slideshow
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References
ViiV. Triumeq Product Information.

https://viivhealthcare.com/en-gb/our-medicines/triumeq/

ViiV. Juluca Product Information.

www.juluca.com/?

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