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Triumeq vs. Odefsey

Reviewed on 3/18/2021

Are Triumeq and Odefsey the Same Thing?

Triumeq (abacavir, dolutegravir, and lamivudine) and Odefsey (emtricitabine, rilpivirine, and tenofovir alafenamide) are combinations of drugs used to treat human immunodeficiency virus type 1 (HIV1) infection.

Triumeq and Odefsey both contain HIV-1 nucleoside analog reverse transcriptase inhibitors (NRTIs). Triumeq also contains an integrase strand transfer inhibitor (INSTI) and Odefsey also contains a non-nucleoside reverse transcriptase inhibitor (NNRTI).

Side effects of Triumeq and Odefsey that are similar include insomnia, headache, nausea, depression, dizziness, and abnormal body fat distribution.

Side effects of Triumeq that are different from Odefsey include fatigue, diarrhea, vomiting, fever, loss of appetite, low energy, nightmares or abnormal dreams, numbness and tingling, hypersensitivity reactions (fever, rash, shortness of breath, cough, or sore throat), joint pain or swelling, muscle pain, extremity swelling, and spinning sensation (vertigo).

Side effects of Odefsey that are different from Triumeq include drowsiness, abdominal pain, rash, and weight gain.

Both Triumeq and Odefsey may interact with antacids or laxatives that contain aluminum or magnesium (Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids, and others).

Triumeq may also interact with dofetilide, sucralfate, buffered medicines, vitamin or mineral supplements that contain calcium or iron, other medicines to treat HIV or AIDS, dalfampridine, St. John's wort, and medicines that contain metformin.

Odefsey may also interact with antimycobacterials, azole antifungals, H2-receptor antagonists, macrolide or ketolide antibiotics, and narcotics.

What Are Possible Side Effects of Triumeq?

Common side effects of Triumeq include:

  • insomnia,
  • headache,
  • fatigue,
  • diarrhea,
  • nausea,
  • vomiting,
  • fever,
  • loss of appetite,
  • low energy,
  • nightmares or abnormal dreams,
  • abnormal body fat distribution,
  • numbness and tingling,
  • hypersensitivity reactions (fever, rash, shortness of breath, cough, or sore throat),
  • joint pain or swelling,
  • muscle pain,
  • extremity swelling,
  • depression,
  • dizziness, and
  • spinning sensation (vertigo).

What Are Possible Side Effects of Odefsey?

Common side effects of Odefsey include:

  • depressive disorders (depressed mood, depression, general unease, mood changes, negative thoughts, suicide attempts, suicidal ideation),
  • insomnia,
  • headache,
  • nausea,
  • drowsiness,
  • dizziness,
  • abdomincal pain,
  • rash,
  • weight gain, and
  • redistribution of body fat.

QUESTION

What is HIV? See Answer

What Is Triumeq?

Triumeq may interact with dofetilide and other drugs. Tell your doctor all medications and supplements you use.

What Is Odefsey?

Odefsey (emtricitabine, rilpivirine, and tenofovir alafenamide) is a combination of two HIV nucleoside analog reverse transcriptase inhibitors (NRTIs) and a non-nucleoside reverse transcriptase inhibitor (NNRTI) indicated as a complete regimen for the treatment of HIV-1 infection in patients 12 years of age and older as initial therapy in those with no antiretroviral treatment history with HIV-1 RNA less than or equal to 100,000 copies per mL; or to replace a stable antiretroviral regimen in those who are virologically-suppressed (HIV-1 RNA less than 50 copies per mL) for at least six months with no history of treatment failure and no known substitutions associated with resistance to the individual components of Odefsey.

What Drugs Interact With Triumeq?

Triumeq may interact with dexamethasone, imatinib, isoniazid, nefazodone, St. John's wort, antibiotics, antifungals, barbiturates, heart or blood pressure medications, HIV/AIDS medicines, medicines to treat narcolepsy, medications to treat osteoporosis or Paget's disease of bone, seizure medications, or grapefruit and grapefruit juice. Tell your doctor all medications and supplements you use.

What Drugs Interact With Odefsey?

Odefsey may interact with antacids, antimycobacterials, azole antifungals, H2-receptor antagonists, macrolide or ketolide antibiotics, and narcotics. Tell your doctor all medications and supplements you use.

How Should Triumeq be Taken?

The adult dose of Triumeq is one tablet daily.

How Should Odefsey be Taken?

The recommended dosage of Odefsey is one tablet taken orally once daily with a meal.

SLIDESHOW

A Timeline of the HIV/AIDS Pandemic See Slideshow
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References
ViiV. Triumeq Product Information.

https://viivhealthcare.com/en-gb/our-medicines/triumeq/

Gilead. Odefsey Product Information.

https://www.odefsey.com/

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