Triumeq vs. Truvada

Reviewed on 3/18/2021

Are Triumeq and Truvada the Same Thing?

Triumeq (abacavir, dolutegravir, and lamivudine) and Truvada (emtricitabine/tenofovir disoproxil fumarate) are used to treat human immunodeficiency virus type 1 (HIV1) infection.

Both Triumeq and Truvada contain an HIV-1 nucleoside analog reverse transcriptase inhibitor (NRTI). Triumeq also contains an integrase strand transfer inhibitor (INSTI).

Side effects of Triumeq and Truvada that are similar include insomnia, headache, diarrhea, nausea, vomiting, abnormal dreams abnormal body fat distribution, joint pain or swelling, depression, and dizziness.

Side effects of Triumeq that are different from Truvada include fatigue, fever, loss of appetite, low energy, nightmares, numbness and tingling, hypersensitivity reactions (fever, rash, shortness of breath, cough, or sore throat), muscle pain, extremity swelling, and spinning sensation (vertigo).

Side effects of Truvada that are different from Triumeq include stomach pain, back pain, itching or skin rash, and changes in the color of skin on your palms or soles of your feet.

Both Triumeq and Truvada may interact with other medicines to treat HIV or AIDS.

Triumeq may also interact with dofetilide, antacids or laxatives that contain aluminum or magnesium (Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids, and others), sucralfate, buffered medicines, vitamin or mineral supplements that contain calcium or iron, dalfampridine, St. John's wort, and medicines that contain metformin.

Truvada may also interact with lithium, methotrexate, pain or arthritis medicines, medicines used to prevent organ transplant rejection, IV antibiotics, cancer medicines, herpes medications, medications to treat cytomegalovirus (CMV).

What Are Possible Side Effects of Triumeq?

Common side effects of Triumeq include:

  • insomnia,
  • headache,
  • fatigue,
  • diarrhea,
  • nausea,
  • vomiting,
  • fever,
  • loss of appetite,
  • low energy,
  • nightmares or abnormal dreams,
  • abnormal body fat distribution,
  • numbness and tingling,
  • hypersensitivity reactions (fever, rash, shortness of breath, cough, or sore throat),
  • joint pain or swelling,
  • muscle pain,
  • extremity swelling,
  • depression,
  • dizziness, and
  • spinning sensation (vertigo).

What Are Possible Side Effects of Truvada?

Common side effects of Truvada include:

  • trouble sleeping (insomnia),
  • tiredness,
  • headache,
  • allergic reactions such as rash,
  • changes in liver tests,
  • changes in body fat (especially in your back, neck, and trunk),
  • changes in your immune system,
  • depression,
  • abnormal dreams,
  • dizziness,
  • headache,
  • nausea,
  • diarrhea,
  • skin rash,
  • fatigue, and
  • spinning sensation (vertigo).


What is HIV? See Answer

What Is Triumeq?

Triumeq may interact with dofetilide and other drugs. Tell your doctor all medications and supplements you use.

What Is Truvada?

Truvada (dolutegravir) is an integrase strand transfer inhibitor (INSTI) used in combination with other antiretroviral agents to treat human immunodeficiency virus type 1 (HIV-1) infection in adults and children aged 12 years and older.

What Drugs Interact With Triumeq?

Triumeq may interact with dexamethasone, imatinib, isoniazid, nefazodone, St. John's wort, antibiotics, antifungals, barbiturates, heart or blood pressure medications, HIV/AIDS medicines, medicines to treat narcolepsy, medications to treat osteoporosis or Paget's disease of bone, seizure medications, or grapefruit and grapefruit juice. Tell your doctor all medications and supplements you use.

What Drugs Interact With Truvada?

Truvada may interact with:

  • other HIV/AIDS medicines;
  • antacids or laxatives that contain aluminum, magnesium or calcium;
  • sucralfate;
  • iron or calcium supplements, or
  • buffered medicines;
  • anti-seizure medicines,
  • St. John's wort,
  • metformin, or
  • rifampin

Tell your doctor all medications and supplements you use.

How Should Triumeq be Taken?

The adult dose of Triumeq is one tablet daily.

How Should Truvada be Taken?

The recommended dose of Truvada is 50 mg administered orally once or twice daily.


A Timeline of the HIV/AIDS Pandemic See Slideshow

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ViiV. Triumeq Product Information.

Gliead. Truvada Product Information.

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