Medical Editor: John P. Cunha, DO, FACOEP
TrophAmine (amino acid) Injections contains essential amino acids and is used for the nutritional support of infants and pediatric patients requiring total parenteral nutrition (TPN). Common side effects of TrophAmine include:
- weight gain
- increase in blood urea nitrogen (BUN)
- increased acidity in the body (acidosis)
- fever, and
- injection site reactions (infection, swelling, warmth, redness, and blood clot)
Recommendations for allowances of protein in infant nutrition have ranged from 2 to 4 grams of protein per kilogram of body weight per day (2.0 to 4.0 g/kg/day). TrophAmine may interact with other drugs or additives. Tell your doctor all medications and supplements you use. During pregnancy, TrophAmine should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
Our TrophAmine (amino acid) Injections Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Reactions reported in clinical studies as a result of infusion of the parenteral fluid were water weight gain, edema, increase in BUN, and mild acidosis.
Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia.
Local reaction at the infusion site, consisting of a warm sensation, erythema, phlebitis and thrombosis, have been reported with peripheral amino acid infusions, especially if other substances are also administered through the same site.
If electrolyte supplementation is required during peripheral infusion, it is recommended that additives be administered throughout the day in order to avoid possible venous irritation. Irritating additive medications may require injection at another site and should not be added directly to the amino acid infusate.
Symptoms may result from an excess or deficit of one or more of the ions present in the solution; therefore, frequent monitoring of electrolyte levels is essential.
Phosphorus deficiency may lead to impaired tissue oxygenation and acute hemolytic anemia. Relative to calcium, excessive phosphorus intake can precipitate hypocalcemia with cramps, tetany and muscular hyperexcitability.
If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.
Read the entire FDA prescribing information for TrophAmine (Amino Acids)
© TrophAmine Patient Information is supplied by Cerner Multum, Inc. and TrophAmine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.