Last updated on RxList: 11/15/2021
Trulance Patient Information Including Side Effects

Brand Names: Trulance

Generic Name: plecanatide

What is plecanatide (Trulance)?

Plecanatide is used to treat chronic idiopathic constipation, or irritable bowel syndrome with constipation.

Plecanatide may also be used for purposes not listed in this medication guide.

What are the possible side effects of plecanatide (Trulance)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Diarrhea is a common side effect of plecanatide. Stop using plecanatide and call your doctor at once if your diarrhea is severe.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about plecanatide (Trulance)?

You should not use plecanatide if you have a blockage in your intestines.

Do not give this medicine to a child younger than 6 years old. Plecanatide is not approved for use by anyone younger than 18 years old.


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Trulance Patient Information including How Should I Take

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What should I discuss with my healthcare provider before taking plecanatide (Trulance)?

You should not use plecanatide if you are allergic to it, or if you have:

  • a blockage in your intestines.

Do not give this medicine to a child younger than 6 years old.

Avoid using plecanatide in anyone younger than 18 years old. In animal studies, plecanatide caused severe dehydration leading to death.

Tell your doctor if you are pregnant or breastfeeding.

How should I take plecanatide (Trulance)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Swallow the tablet whole, with or without food.

If you cannot swallow the tablet whole, you may crush and mix the tablet with a spoonful of water or applesauce. Swallow this mixture right away. Do not save it for later use.

This tablet mixture with water may also be given through a nasogastric (NG) feeding tube using a catheter-tipped syringe. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Store at room temperature away from moisture and heat.

Keep the tablets in their original bottle or blister pack until you are ready to take one. You may remove the packing coil from inside the pill bottle. But leave the packet or canister of moisture-absorbing preservative inside the bottle.


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Trulance Patient Information including If I Miss a Dose

What happens if I miss a dose (Trulance)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose (Trulance)?

An overdose of plecanatide is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication. A child under 6 who takes this medicine may become severely dehydrated.

What should I avoid while taking plecanatide (Trulance)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect plecanatide (Trulance)?

Other drugs may affect plecanatide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information (Trulance)?

Your pharmacist can provide more information about plecanatide.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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