Tussigon Side Effects Center

Last updated on RxList: 10/25/2022
Tussigon Side Effects Center

What Is Tussigon?

Tussigon Tablets (hydrocodone bitartrate and homatropine methylbromide) is a combination of a narcotic cough medicine and a medicine that works against the narcotic to prevent an overdose used to treat cough.

What Are Side Effects of Tussigon?

Tussigon may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • interrupted breathing during sleep,
  • stomach pain,
  • mental or mood changes,
  • agitation,
  • confusion,
  • hallucinations,
  • difficult or painful urination,
  • eye pain,
  • swelling or redness of the eye,
  • vision changes,
  • seeing halos around lights,
  • blurred vision,
  • slow, shallow or irregular breathing,
  • severe drowsiness,
  • difficulty waking up,
  • seizure,
  • fainting, and
  • severe dizziness

Get medical help right away, if you have any of the symptoms listed above.

Common side effects of Tussigon include:

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Tussigon

The adult dose of Tussigon is one (1) tablet every 4 to 6 hours as needed; do not exceed six (6) tablets in 24 hours. The dose of Tussigon for children 6 to 12 years of age is one-half (1/2) tablet every 4 to 6 hours as needed; do not exceed three (3) tablets in 24 hours.

What Drugs, Substances, or Supplements Interact with Tussigon?

Tussigon may interact with narcotics, antihistamines, antipsychotics, antianxiety agents, other CNS depressants (including alcohol), MAO inhibitors, and tricyclic antidepressants. Tell your doctor all medications and supplements you use.

Tussigon During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Tussigon; it is unknown how it will affect a fetus. Babies born to mothers who have been taking opioids such as hydrocodone in Tussigon regularly prior to delivery will be physically dependent. It is unknown if Tussigon passes into breast milk. Breastfeeding while using Tussigon is not recommended. Withdrawal symptoms may occur if you suddenly stop taking Tussigon.

Additional Information

Our Tussigon Tablets (hydrocodone bitartrate and homatropine methylbromide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Cold and Flu: Finding Relief for Your Cough See Slideshow
Tussigon Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Stop taking this medicine and call your doctor at once if you have:

  • noisy breathing, sighing, shallow breathing;
  • extreme drowsiness, confusion, feeling weak or limp;
  • a seizure;
  • a light-headed feeling, like you might pass out;
  • severe constipation, stomach pain;
  • little or no urination;
  • adrenal gland problems--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or
  • high levels of serotonin in the body--agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea.

Serious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders.

Common side effects may include:

  • drowsiness, dizziness;
  • lack of energy, coordination problems;
  • headache, confusion;
  • dry mouth, nausea, vomiting, constipation;
  • tremors, fast or irregular heart rate; or
  • feeling anxious, restless, nervous, or irritable.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Which illness is known as a viral upper respiratory tract infection? See Answer
Tussigon Professional Information


Central Nervous System

Sedation, drowsiness, mental clouding, lethargy, impairment of mental and physical performance, anxiety, fear, dysphoria, dizziness, psychic dependence, mood changes.

Gastrointestinal System

Nausea and vomiting may occur; they are more frequent in ambulatory than in recumbent patients.

Prolonged administration of TUSSIGON may produce constipation.

Genitourinary System

Ureteral spasm, spasm of vesicle sphincters and urinary retention have been reported with opiates.

Respiratory Depression

TUSSIGON may produce dose-related respiratory depression by acting directly on brain stem respiratory centers (see OVERDOSE).


Skin rash, pruritus.

Read the entire FDA prescribing information for Tussigon (Hydrocodone Bitartrate and Homatropine Methylbromide Tablets)

© Tussigon Patient Information is supplied by Cerner Multum, Inc. and Tussigon Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

Health Solutions From Our Sponsors