Tussionex Side Effects Center

Last updated on RxList: 6/29/2022
Tussionex Side Effects Center

What Is Tussionex?

Tussionex (chlorpheniramine and hydrocodone) is a combination antihistamine/antitussive drug prescribed for symptomatically managing cold and allergy symptoms.

What Are Side Effects of Tussionex?

Common side effects of Tussionex include:

Contact your doctor if you have serious side effects of Tussionex including:

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Tussionex

Tussionex usual dose is 5 ml twice a day.

What Drugs, Substances, or Supplements Interact with Tussionex?

Tussionex may interact with other drugs that can cause sleepiness (narcotics, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety), any other cold or allergy medicines, atropine, benztropine, dimenhydrinate, methscopolamine, scopolamine, bronchodilators, glycopyrrolate, mepenzolate, bladder or urinary medications, irritable bowel medications, or MAO inhibitors. Tell your doctor all medications and supplements you use.

Tussionex During Pregnancy or Breastfeeding

Tussionex should not be used during pregnancy as it may cause adverse effects in the fetus unless the potential benefit outweighs the potential unknown risk to the fetus. Tussionex is secreted in human breast milk and may cause adverse effects in the new born. Consult your doctor before breastfeeding.

Additional Information

Our Tussionex Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Could I Be Allergic? Discover Your Allergy Triggers See Slideshow
Tussionex Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Like other narcotic medications, hydrocodone can slow your breathing. Death may occur if breathing becomes too weak.

A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Stop using this medicine and call your doctor at once if you have:

  • severe drowsiness;
  • noisy breathing, sighing, shallow breathing;
  • severe constipation;
  • a light-headed feeling, like you might pass out;
  • a slow heart rate or weak pulse;
  • confusion; or
  • adrenal gland problems--nausea, vomiting, loss of appetite, dizziness, feeling weak or tired.

Side effects such as dry mouth, constipation, and confusion may be more likely in older adults.

Common side effects may include:

  • trouble breathing;
  • drowsiness;
  • confusion;
  • nausea, vomiting; or
  • little or no urination.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Tussionex (Hydrocodone and Chlorpheniramine)


Allergies can best be described as: See Answer
Tussionex Professional Information


Gastrointestinal Disorders

Nausea and vomiting may occur; they are more frequent in ambulatory than in recumbent patients. Prolonged administration of TUSSIONEX Pennkinetic Extended-Release Suspension may produce constipation.

General Disorders And Administration Site Conditions


Nervous System Disorders

Sedation, drowsiness, mental clouding, lethargy, impairment of mental and physical performance, anxiety, fear, dysphoria, euphoria, dizziness, psychic dependence, mood changes.

Renal And Urinary Disorders

Ureteral spasm, spasm of vesical sphincters, and urinary retention have been reported with opiates.

Respiratory, Thoracic And Mediastinal Disorders

Dryness of the pharynx, occasional tightness of the chest, and respiratory depression (see CONTRAINDICATIONS).

TUSSIONEX Pennkinetic Extended-Release Suspension may produce dose-related respiratory depression by acting directly on brain stem respiratory centers (see OVERDOSE). Use of TUSSIONEX Pennkinetic Extended-Release Suspension in children less than 6 years of age has been associated with fatal respiratory depression. Overdose with TUSSIONEX Pennkinetic Extended- Release Suspension in children 6 years of age and older, in adolescents, and in adults has been associated with fatal respiratory depression.

Skin And Subcutaneous Tissue Disorders

Rash, pruritus.

Read the entire FDA prescribing information for Tussionex (Hydrocodone and Chlorpheniramine)

© Tussionex Patient Information is supplied by Cerner Multum, Inc. and Tussionex Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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