Tussionex vs. Hycodan

Are Hycodan and Tussionex the Same Thing?

Tussionex (chlorpheniramine and hydrocodone) and Hycodan (hydrocodone bitartrate and homatropine methylbromide) are combinations that include narcotic cough medicines used to treat cough.

Tussionex is combined with an antihistamine and is also used to manage cold and allergy symptoms.

Hycodan is combined with an anticholinergic medicine that works against the narcotic to prevent an overdose.


Cold and Flu: Finding Relief for Your Cough See Slideshow

What Are Possible Side Effects of Tussionex?

Common side effects of Tussionex include:

Contact your doctor if you have serious side effects of Tussionex including:

What Are Possible Side Effects of Hycodan?

Common side effects of Hycodan include:

  • nausea due to the use of hydrocodone, which usually goes away after the first few doses.

Other side effects of Hycodan include:

  • lightheadedness,
  • dizziness,
  • drowsiness,
  • vision changes,
  • trouble concentrating,
  • vomiting,
  • constipation, or
  • skin itching or rash.

Tell your doctor if you have serious side effects of Hycodan including:

What Is Tussionex?

Tussionex (chlorpheniramine and hydrocodone) is a combination antihistamine/antitussive drug prescribed for symptomatically managing cold and allergy symptoms.

What Is Hycodan?

Hycodan (hydrocodone bitartrate and homatropine methylbromide) is a combination of a narcotic cough medicine and a medicine that works against the narcotic to prevent an overdose used to treat cough.


Which illness is known as a viral upper respiratory tract infection? See Answer

What Drugs Interact With Tussionex?

Tussionex may interact with other drugs that can cause sleepiness (narcotics, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety), any other cold or allergy medicines, atropine, benztropine, dimenhydrinate, methscopolamine, scopolamine, bronchodilators, glycopyrrolate, mepenzolate, bladder or urinary medications, irritable bowel medications, or MAO inhibitors. Tell your doctor all medications and supplements you use.

What Drugs Interact With Hycodan?

Hycodan may interact with other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). Tell your doctor all medications you use.

How Should Tussionex Be Taken?

Tussionex usual dose is 5 ml twice a day.

How Should Hycodan Be Taken?

The dose of Hycodan for adults and children 12 years and older is one tablet or 5 mL (1 tsp) of the oral solution every 4 to 6 hours as needed; do not exceed six tablets or 30 mL (6 tsp) in 24 hours. Consult your doctor for pediatric dosing.


All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.


FDA. Tussionex Prescribing Information.
FDA. Hycodan Prescribing Information.

Health Solutions From Our Sponsors