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Last reviewed on RxList: 2/2/2021
Tuxarin-ER Side Effects Center

What Is Tuxarin ER?

Tuxarin ER (codeine phosphate and chlorpheniramine maleate) extended release tablets are a combination of an opiate agonist antitussive and a histamine-1 (H1) receptor antagonist indicated for the relief of cough and symptoms associated with upper respiratory allergies or a common cold. Tuxarin ER is available in generic form.

What Are Side Effects of Tuxarin ER?

Common side effects of Tuxarin ER include:

Psychological dependence, physical dependence, and tolerance may develop upon repeated use of Tuxarin ER.

Dosage for Tuxarin ER

The dose of Tuxarin ER for adults and children 18 years of age and older is 1 tablet every 12 hours, not to exceed 2 doses in 24 hours.

What Drugs, Substances, or Supplements Interact with Tuxarin ER?

Tuxarin ER may interact with benzodiazepines, opioids, antihistamines, antipsychotics, anti-anxiety agents, other central nervous system depressants (including alcohol), monoamine oxidase inhibitors, tricyclic antidepressants, anticholinergics, and phenytoin. Tell your doctor all medications and supplements you use.

Tuxarin ER During Pregnancy and Breastfeeding

Tuxarin ER is not recommended for use during pregnancy; it may harm a fetus. Use of Tuxarin ER shortly before delivery may result in respiratory depression in a newborn. Tuxarin ER passes into breast milk and may have adverse effects on nursing infants. Consult your doctor before breastfeeding. Withdrawal symptoms may occur if you suddenly stop taking Tuxarin ER.

Additional Information

Our Tuxarin ER (codeine phosphate and chlorpheniramine maleate) Extended Release Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Tuxarin-ER Professional Information

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Use of codeine, an opioid, may result in the following:

Use of chlorpheniramine, an antihistamine, may result in:

  • Decreased mental alertness with impaired mental and/or physical abilities [see WARNINGS AND PRECAUTIONS]

Adverse reactions listed below have been reported in the literature for codeine and chlorpheniramine and may be expected to occur with TUXARIN ER. Also included are events that occurred during clinical pharmacokinetic studies (in a total of 66 healthy adult volunteers with either single or multiple dose exposure) with TUXARIN ER and judged by the investigator to be related to study treatment. Because these reactions may be reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.


Allergic laryngospasm, nasal stuffiness, bronchospastic allergic reaction, hives, itching, swelling of face.

Body As A whole

Asthenia, feeling of relaxation, redness or flushing of the face, unusual tiredness, weakness. Cardiovascular: Fast, or slow heartbeat, hypertension, hypotension, orthostatic hypotension, palpitations, shock-like state, syncope.

Dermatological System

Skin rash, pruritus, erythema, urticaria, excessive perspiration, dermatitis.

Endocrine System

Changes in glucose utilization, decreased lactation, early menses, glycosuria, gynecomastia, hypoglycemia, increased appetite, increased libido, pheochromocytoma stimulation.

Gastrointestinal System

Nausea and vomiting,, constipation, abdominal distension, abdominal pain, acute pancreatitis, dry mouth, dyspepsia, epigastric distress, loss of appetite, diarrhea, gastro-esophageal reflux, gastrointestinal hypomotility.

Genitourinary System

Ureteral spasm, urinary retention, dysuria, urinary frequency, urinary hesitancy, irritative bladder symptom.

Nervous System

Blurred vision, diplopia, visual disturbances, confusion, dizziness, depression, drowsiness, sedation, headache, euphoria, facial dyskinesia, false sense of well-being, feeling faint, lightheadedness, general feeling of discomfort or illness, excitability nervousness, agitation, restlessness, somnolence, insomnia, dyskinesia, irritability, tremor.


Dryness of the pharynx and respiratory passages, laryngismus, atelectasis, wheezing, troubled breathing, respiratory depression, hiccups.

Special Senses

labyrinthitis, tinnitus, vertigo, hypermetropia, lacrimation increased, mydriasis, photophobia.

Read the entire FDA prescribing information for Tuxarin-ER (Codeine Phosphate and Chlorpheniramine Maleate Extended Release Tablets, CIII)


The common cold is one of the most common illnesses in the world. See Answer
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© Tuxarin-ER Patient Information is supplied by Cerner Multum, Inc. and Tuxarin-ER Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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