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Tuzistra XR

Last reviewed on RxList: 9/12/2017
Tuzistra XR Side Effects Center

Last reviewed on RxList 09/12/2017

Tuzistra XR (codeine polistirex and chlorpheniramine polistirex) extended-release oral suspension is a combination of an opiate agonist antitussive and a histamine-1 (H1) receptor antagonist indicated for relief of cough and symptoms associated with upper respiratory allergies or a common cold. Common side effects of Tuzistra XR include:P

The adult dose of Tuzistra XR is 10 mL every 12 hours, not to exceed 2 doses (20 mL) in 24 hours. Tuzistra XR may interact with other opioids, antihistamines, antipsychotics, anti-anxiety agents, other CNS depressants, MAOIs, tricyclic antidepressants, anticholinergics, and phenytoin or other inhibitors or inducers of metabolic enzymes. Tell your doctor all medications and supplements you use. Tuzistra XR is not recommended for use during pregnancy; it may harm a fetus. Codeine passes into breast milk and may cause undesirable side effects in a nursing infant. Consult your doctor before breastfeeding. Withdrawal symptoms may occur if you suddenly stop taking Tuzistra XR.

Our Tuzistra XR (codeine polistirex and chlorpheniramine polistirex) extended-release oral suspension Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Allergies can best be described as: See Answer
Tuzistra XR Professional Information


Use of codeine, a semisynthetic opioid, may result in the following:

Use of chlorpheniramine, an antihistamine, may result in:

  • Decreased mental alertness with impaired mental and/or physical abilities [see WARNINGS AND PRECAUTIONS]

Adverse reactions listed below have been reported in the literature for codeine and chlorpheniramine and may be expected to occur with TUZISTRA XR. Also included are events that occurred during clinical pharmacokinetic studies (in a total of 66 healthy adult volunteers with either single or multiple dose exposure) with TUZISTRA XR and judged by the investigator to be related to study treatment. Because these reactions may be reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.


Allergic laryngospasm, nasal stuffiness, bronchospastic allergic reaction, hives, itching, swelling of face.

Body As A Whole

Asthenia, feeling of relaxation, redness or flushing of the face, unusual tiredness, weakness.


Fast, or slow heartbeat, hypertension, hypotension, orthostatic hypotension, palpitations, shock-like state, syncope.

Dermatological System

Skin rash, pruritus, erythema, urticaria, excessive perspiration, dermatitis.

Endocrine System

Changes in glucose utilization, decreased lactation, early menses, glycosuria, gynecomastia, hypoglycemia, increased appetite, increased libido, pheochromocytoma stimulation.

Gastrointestinal System

Nausea and vomiting, constipation, abdominal distension, abdominal pain, acute pancreatitis, dry mouth, dyspepsia, epigastric distress, loss of appetite, diarrhea, gastro-esophageal reflux, gastrointestinal hypomotility.

Genitourinary System

Ureteral spasm, urinary retention, dysuria, urinary frequency, urinary hesitancy, irritative bladder symptom.

Nervous System

Blurred vision, diplopia, visual disturbances, confusion, dizziness, depression, drowsiness, sedation, headache, euphoria, facial dyskinesia, false sense of well-being, feeling faint, lightheadedness, general feeling of discomfort or illness, excitability, nervousness, agitation, restlessness, somnolence, insomnia, dyskinesia, irritability, tremor.


Dryness of the pharynx and respiratory passages, laryngismus, atelectasis, wheezing, troubled breathing, respiratory depression, hiccups.

Special Senses

labyrinthitis, tinnitus, vertigo, hypermetropia, lacrimation increased, mydriasis, photophobia.

Read the entire FDA prescribing information for Tuzistra XR (Codeine Polistirex, Chlorpheniramine Polistirex Extended-release Oral Suspension)


Could I Be Allergic? Discover Your Allergy Triggers See Slideshow
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© Tuzistra XR Patient Information is supplied by Cerner Multum, Inc. and Tuzistra XR Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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