Tyrvaya

Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 5/24/2022
Tyrvaya Side Effects Center

What Is Tyrvaya?

Tyrvaya (varenicline solution) nasal spray is a cholinergic agonist indicated for the treatment of the signs and symptoms of dry eye disease.

What Are Side Effects of Tyrvaya?

Side effects of Tyrvaya include:

  • sneezing,
  • cough,
  • throat irritation, and
  • instillation-site (nose) irritation.

Dosage for Tyrvaya

The dose of Tyrvaya is one spray in each nostril twice daily (approximately 12 hours apart). Prime with seven (7) actuations before initial use. Re-prime with 1 actuation if not used for more than five (5) days.

Tyrvaya In Children

Safety and efficacy of Tyrvaya in pediatric patients have not been established.

What Drugs, Substances, or Supplements Interact with Tyrvaya?

Tyrvaya may interact with other medicines.

Tell your doctor all medications and supplements you use.

Tyrvaya During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Tyrvaya; it is unknown how it could affect a fetus. It is unknown if Tyrvaya passes into breast milk.  Consult your doctor before breastfeeding.

Additional Information

Our Tyrvaya (varenicline solution) Nasal Spray Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

What causes dry eyes? See Answer
Tyrvaya Professional Information

SIDE EFFECTS

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

In three clinical studies of dry eye disease conducted with varenicline solution nasal spray, 349 patients received at least 1 dose of TYRVAYA. The majority of patients had 31 days of treatment exposure, with a maximum exposure of 105 days.

The most common adverse reactions reported in 82% of TYRVAYA treated patients was sneezing. Other common adverse reactions that were reported in >5% of patients include cough (16%), throat irritation (13%), and instillation-site (nose) irritation (8%).

DRUG INTERACTIONS

No Information provided

Read the entire FDA prescribing information for Tyrvaya (Varenicline Solution Nasal Spray)

SLIDESHOW

Pink Eye (Conjunctivitis) Symptoms, Causes, Treatments See Slideshow

© Tyrvaya Patient Information is supplied by Cerner Multum, Inc. and Tyrvaya Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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