Ulcer, esophageal: A hole in the lining of the esophagus (tube-like organ leading from the throat to the stomach) corroded by the acidic digestive juices secreted by the stomach cells. Ulcer formation is related to H. pyloridus bacteria in the stomach, anti-inflammatory medications, and smoking cigarettes. Ulcer pain may not correlate with the presence or severity of ulceration. Diagnosis is made with barium x-ray or endoscopy. Complications of ulcers include bleeding and perforation. Treatment involves antibiotics to eradicate H. pyloridus, eliminating risk factors, and preventing complications.