Unasyn vs. Rocephin

Are Unasyn and Rocephin the Same Thing?

Unasyn (ampicillin sodium/sulbactam sodium) and Rocephin (ceftriaxone sodium) are antibiotics used to treat bacterial infections.

Rocephin is also used to treat severe or life-threatening infections such as meningitis.

Unasyn and Rocephin are different types of antibiotics. Unasyn is a combination of a penicillin-type antibiotic and a beta-lactamase inhibitor and Rocephin is a cephalosporin antibiotic.

Side effects of Unasyn and Rocephin that are similar include headache, diarrhea, nausea, vomiting, vaginal itching or discharge, and injection site reactions (swelling, redness, pain, a hard lump, irritation, or soreness).

Side effects of Unasyn that are different from Rocephin include fever, sore throat, rash, body aches, stomach pain, bloating, gas, itching, swollen/black/"hairy" tongue, and thrush (white patches inside your mouth or throat).

Side effects of Rocephin that are different from Unasyn include loss of appetite, upset stomach, dizziness, overactive reflexes, pain or swelling in your tongue, and sweating.

Unasyn may interact with allopurinol or probenecid.

Rocephin may interact with other drugs.

What Are Possible Side Effects of Unasyn?

Common side effects of Unasyn include:

  • fever,
  • sore throat,
  • headache,
  • rash,
  • diarrhea,
  • body aches,
  • nausea,
  • vomiting,
  • stomach pain,
  • bloating,
  • gas,
  • vaginal itching or discharge,
  • itching,
  • swollen/black/"hairy" tongue,
  • thrush (white patches inside your mouth or throat), or
  • pain, swelling, or irritation where the needle is placed.

What Are Possible Side Effects of Rocephin?

Common side effects of Rocephin include:

  • injection site reactions (swelling, redness, pain, a hard lump, or soreness),
  • loss of appetite,
  • nausea,
  • vomiting,
  • upset stomach,
  • diarrhea,
  • headache,
  • dizziness,
  • overactive reflexes,
  • pain or swelling in your tongue,
  • sweating, or
  • vaginal itching or discharge.

What Is Unasyn?

Unasyn (ampicillin sodium/sulbactam sodium) is a combination antibiotic indicated for the treatment of infections due to susceptible strains of microorganisms.

What Is Rocephin?

Rocephin (ceftriaxone sodium) for Injection is a cephalosporin antibiotic used to treat many kinds of bacterial infections, including severe or life-threatening forms such as meningitis. Rocephin is available in generic form.


Bowel regularity means a bowel movement every day. See Answer

What Drugs Interact With Unasyn?

Unasyn may interact with allopurinol, probenecid, or other antibiotics.

What Drugs Interact With Rocephin?

Rocephin may interact with other drugs.

How Should Unasyn Be Taken?

Unasyn is administered orally in the form of tablets.

How Should Rocephin Be Taken?

The usual adult daily dose is 1 to 2 grams given once a day (or in equally divided doses twice a day) depending on the type and severity of infection. Pediatric dosing depends on the condition being treated and the child's weight. Other drugs may interact with Rocephin.


Fungal Skin Infections: Types, Symptoms, and Treatments See Slideshow

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.


Pfizer. Unasyn Product Information.


Medscape. Rocephin Product Information.


Health Solutions From Our Sponsors