Uptravi vs. Letairis

Reviewed on 8/19/2020

Are Uptravi and Letairis the Same Thing?

Uptravi (selexipag) and Letairis (ambrisentan) are used to treat pulmonary arterial hypertension.

Uptravi and Letairis belong to different drug classes. Uptravi is a prostacyclin receptor agonist and Letairis is an endothelin receptor antagonist.

Side effects of Uptravi and Letairis that are similar include headache, vomiting, and flushing (warmth, redness, or tingly feeling).

Side effects of Uptravi that are different from Letairis include diarrhea, jaw pain, nausea, muscle pain, pain in extremities, joint pain, low levels of iron in the blood (anemia), decreased appetite, and rash.

Side effects of Letairis that are different from Uptravi include stuffy nose, runny nose, sinus pain, abdominal or stomach pain, constipation, and sore throat.

Both Uptravi and Letairis may interact with rifampin.

Uptravi may also interact with gemfibrozil, teriflunomide, and deferasirox.

Letairis may also interact with cyclosporine, omeprazole, antibiotics, and HIV medicines.

What Are Possible Side Effects of Uptravi?

Common side effects of Uptravi include:

Side effects of Uptravi include:

  • headache,
  • diarrhea,
  • jaw pain,
  • nausea,
  • muscle pain,
  • vomiting,
  • pain in extremities,
  • flushing (warmth, redness, or tingly feeling),
  • joint pain,
  • low levels of iron in the blood (anemia),
  • decreased appetite, or
  • rash

What Are Possible Side Effects of Letairis?

Common side effects of Letairis include:

Tell your doctor if you have unlikely but serious side effects of Letairis including:

  • fast heartbeat,
  • extreme tiredness,
  • swelling ankles or feet,
  • sudden or unexplained weight gain, or
  • trouble breathing.


COPD (chronic obstructive pulmonary disease) is the same as adult-onset asthma. See Answer

What Is Uptravi?

Uptravi (selexipag) is a prostacyclin receptor agonist indicated for the treatment of pulmonary arterial hypertension (PAH, WHO Group I) to delay disease progression and reduce the risk of hospitalization for PAH.

What Is Letairis?

Letairis (ambrisentan) is an endothelin receptor antagonist used to treat pulmonary arterial hypertension (PAH). Letairis blocks the effects of endothelin-1, helping to decrease the blood pressure in the lungs, slow the worsening of symptoms, and improve your ability to exercise.

What Drugs Interact With Uptravi?

Uptravi may interact with strong inhibitors of CYP2C8 (e.g., gemfibrozil). Tell your doctor all medications and supplements you use.

What Drugs Interact With Letairis?

Letairis may interact with cyclosporine, omeprazole, rifampin, antibiotics, or HIV medicines. Tell your doctor all medications you use.

How Should Uptravi be Taken?

The starting dose of Uptravi is 200 mcg twice daily. Increase the dose of Uptravi by 200 mcg twice daily at weekly intervals to the highest tolerated dose up to 1600 mcg twice daily.

How Should Letairis be Taken?

The adult starting dose of Letairis is 5 mg once daily, and may be increased to 10 mg once daily if 5 mg is tolerated.


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Actelion Pharmaceuticals Ltd. Uptravi Product Information.


Gilead. Letairis Product Informtion


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