How Do Uroprotectants Work?

Reviewed on 11/8/2021

HOW DO UROPROTECTANTS WORK?

Uroprotectants are a class of drugs used as a prophylactic agent to reduce the risk of hemorrhagic cystitis (a condition that causes inflammation of the bladder and can result in severe bleeding) which is a very serious side effect of treatment with ifosfamide (cancer chemotherapy medication). 

Mesna is the only drug that belongs to this drug class. Mesna helps to minimize damage to the epithelium of the urinary tract and protect the lining of the bladder against damage from ifosfamide, a urotoxic chemotherapy medication.

Ifosfamide is broken down to a harmful product called “acrolein” by the body and accumulates in the bladder. Mesna forms a conjugate with acrolein and other urotoxic metabolites which inactivates the urotoxic compounds to harmless metabolites.

Uroprotectants are administered via injectable and oral routes, typically two to six hours after chemotherapy treatment.

Uroprotectants belong to a class of medications called "cytoprotectants" that work by protecting the bladder against some of the harmful effects of chemotherapy medications.

HOW ARE UROPROTECTANTS USED?

Uroprotectants are used to prevent ifosfamide-induced hemorrhagic cystitis.

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WHAT ARE SIDE EFFECTS OF UROPROTECTANTS?

Some of the common side effects include:

Other rare side effects include:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF UROPROTECTANTS?

Generic and brand names of uroprotectants include:

References
https://reference.medscape.com/drugs/uroprotectants

https://medlineplus.gov/druginfo/meds/a613013.html

https://www.rxlist.com/mesnex-drug.htm#indications

https://www.webmd.com/drugs/2/drug-63804/mesna-oral/details

https://www.medicinenet.com/mesna-injection/article.htm

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