Valtoco vs. Nayzilam

Valtoco (diazepam nasal spray) and Nayzilam (midazolam) are benzodiazepines used for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern.

Valtoco is used in patients with epilepsy 6 years of age and older.

Nayzilam is used in patients with epilepsy 12 years of age and older.

Side effects of Valtoco and Nayzilam that are similar include drowsiness, headache, and nasal discomfort.

Side effects of Valtoco that are different from Nayzilam include diarrhea, loss of coordination, dizziness, euphoria, rash, and asthma.

Side effects of Nayzilam that are different from Valtoco include throat irritation and runny nose.

Both Valtoco and Nayzilam may interact with other drugs that can make you sleepy (other benzodiazepines and sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, opioids, alcohol) and ketoconazole.

Valtoco may also interact with cimetidine, quinidine, tranylcypromine, troleandomycin, clotrimazole, carbamazepine, phenytoin, dexamethasone, phenobarbital, omeprazole, propranolol, imipramine, cyclosporine, paclitaxel, terfenadine, theophylline, and warfarin.

Nayzilam may also interact with itraconazole and clarithromycin.

Abrupt discontinuation of chronic Valtoco or Nayzilam use may result in withdrawal symptoms, such as convulsions, tremor, abdominal and muscle cramps, vomiting and sweating, and may also be associated with a temporary increase in the frequency and/or severity of seizures.

Side effects of Valtoco include:

• drowsiness,
• headache,
• nasal discomfort,
• diarrhea,
• loss of coordination,
• dizziness,
• euphoria,
• rash, and
• asthma

Common side effects of Nayzilam include:

• drowsiness,
• headache,
• nasal discomfort,
• throat irritation, and
• runny nose

Valtoco (diazepam nasal spray) is a benzodiazepine used for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient’s usual seizure pattern in patients with epilepsy 6 years of age and older.

Nayzilam (midazolam) is a benzodiazepine indicated for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern in patients with epilepsy 12 years of age and older.

Valtoco may interact with drug such as:

• opioids,
• other CNS depressants (e.g., valproate),
• alcohol,
• cimetidine,
• quinidine,
• tranylcypromine,
• ketoconazole,
• troleandomycin,
• clotrimazole,
• carbamazepine,
• phenytoin,
• dexamethasone,
• phenobarbital,
• omeprazole,
• propranolol,
• imipramine,
• cyclosporine,
• paclitaxel,
• terfenadine,
• theophylline, and
• warfarin

Nayzilam may interact with other drugs that can make you sleepy (other benzodiazepines and sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, opioids, alcohol), ketoconazole, itraconazole, and clarithromycin. Tell your doctor all medications and supplements you use.

Valtoco 5 mg and 10 mg doses are administered as a single spray intranasally into one nostril. Administration of 15 mg and 20 mg doses requires two nasal spray devices, one spray into each nostril. A second dose, when required, may be administered at least 4 hours after the initial dose.

The initial dose of Nayzilam is one spray (5 mg dose) administered into one nostril. A second dose of one additional spray (5 mg dose) Nayzilam may be administered into the opposite nostril after 10 minutes if the patient has not responded to the initial dose.