Valtoco vs. Nayzilam

Are Valtoco and Nayzilam the Same Thing?

Valtoco (diazepam nasal spray) and Nayzilam (midazolam) are benzodiazepines used for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern.

Valtoco is used in patients with epilepsy 6 years of age and older.

Nayzilam is used in patients with epilepsy 12 years of age and older.

Side effects of Valtoco and Nayzilam that are similar include drowsiness, headache, and nasal discomfort.

Side effects of Valtoco that are different from Nayzilam include diarrhea, loss of coordination, dizziness, euphoria, rash, and asthma.

Side effects of Nayzilam that are different from Valtoco include throat irritation and runny nose.

Both Valtoco and Nayzilam may interact with other drugs that can make you sleepy (other benzodiazepines and sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, opioids, alcohol) and ketoconazole.

Valtoco may also interact with cimetidine, quinidine, tranylcypromine, troleandomycin, clotrimazole, carbamazepine, phenytoin, dexamethasone, phenobarbital, omeprazole, propranolol, imipramine, cyclosporine, paclitaxel, terfenadine, theophylline, and warfarin.

Nayzilam may also interact with itraconazole and clarithromycin.

Abrupt discontinuation of chronic Valtoco or Nayzilam use may result in withdrawal symptoms, such as convulsions, tremor, abdominal and muscle cramps, vomiting and sweating, and may also be associated with a temporary increase in the frequency and/or severity of seizures.

What Are Possible Side Effects of Valtoco?

Side effects of Valtoco include:

  • drowsiness,
  • headache,
  • nasal discomfort,
  • diarrhea,
  • loss of coordination,
  • dizziness,
  • euphoria,
  • rash, and
  • asthma

What Are Possible Side Effects of Nayzilam?

Common side effects of Nayzilam include:

  • drowsiness,
  • headache,
  • nasal discomfort,
  • throat irritation, and
  • runny nose

QUESTION

If you have had a seizure, it means you have epilepsy. See Answer

What is Valtoco?

Valtoco (diazepam nasal spray) is a benzodiazepine used for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient’s usual seizure pattern in patients with epilepsy 6 years of age and older.

What is Nayzilam?

Nayzilam (midazolam) is a benzodiazepine indicated for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern in patients with epilepsy 12 years of age and older.

What Drugs Interact With Valtoco?

Valtoco may interact with drug such as:

  • opioids,
  • other CNS depressants (e.g., valproate),
  • alcohol,
  • cimetidine,
  • quinidine,
  • tranylcypromine,
  • ketoconazole,
  • troleandomycin,
  • clotrimazole,
  • carbamazepine,
  • phenytoin,
  • dexamethasone,
  • phenobarbital,
  • omeprazole,
  • propranolol,
  • imipramine,
  • cyclosporine,
  • paclitaxel,
  • terfenadine,
  • theophylline, and
  • warfarin

What Drugs Interact With Nayzilam?

Nayzilam may interact with other drugs that can make you sleepy (other benzodiazepines and sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, opioids, alcohol), ketoconazole, itraconazole, and clarithromycin. Tell your doctor all medications and supplements you use.

How Should Valtoco be Taken?

Valtoco 5 mg and 10 mg doses are administered as a single spray intranasally into one nostril. Administration of 15 mg and 20 mg doses requires two nasal spray devices, one spray into each nostril. A second dose, when required, may be administered at least 4 hours after the initial dose.

How Should Nayzilam be Taken?

The initial dose of Nayzilam is one spray (5 mg dose) administered into one nostril. A second dose of one additional spray (5 mg dose) Nayzilam may be administered into the opposite nostril after 10 minutes if the patient has not responded to the initial dose.

Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
Neurelis. Valtoco Drug Information.

www.valtoco.com

FDA. Nayzilam Drug Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211321s000lbl.pdf

Health Solutions From Our Sponsors