Vectical Side Effects Center

Last updated on RxList: 1/13/2022
Vectical Side Effects Center

What Is Vectical?

Vectical (calcitriol ointment) topical (for the skin) is a form of Vitamin D used to treat plaque psoriasis (raised, silvery flaking of the skin) in adults.

What Are Side Effects of Vectical?

Common side effects of Vectical include application site reactions (pain, burning, itching, redness, irritation, or peeling), and high levels of calcium in the blood (hypercalcemia).

Dosage for Vectical

Apply Vectical Ointment to affected areas twice daily, morning and evening. The maximum weekly dose should not exceed 200 grams.

What Drugs, Substances, or Supplements Interact with Vectical?

Vectical may interact with other medicines to treat psoriasis, vitamin or mineral supplements that contain calcium or vitamin D, or diuretics (water pills). Tell your doctor all medications and supplements you use.

Vectical During Pregnancy and Breastfeeding

During pregnancy, Vectical should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Vectical (calcitriol ointment) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Psoriasis causes the top layer of skin cells to become inflamed and grow too quickly and flake off. See Answer
Vectical Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • blistering, or severe redness, itching, or other irritation of treated areas; or
  • worsened symptoms or no improvement in psoriasis.

Using calcitriol topical can affect your body's ability to metabolize calcium. Tell your doctor right away if you have symptoms of high levels of calcium in your blood (hypercalcemia), including:

  • nausea, vomiting, loss of appetite, constipation;
  • increased thirst or urination;
  • lack of energy, feeling tired;
  • muscle weakness;
  • confusion; or
  • bone pain.

Common side effects may include:

  • high levels of calcium in your blood or urine;
  • itching, skin irritation; or
  • abnormal lab tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

Types of Psoriasis: Medical Pictures and Treatments See Slideshow
Vectical Professional Information

SIDE EFFECTS

Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice.

Clinical Studies Experience

VECTICAL Ointment was studied in two vehicle-controlled studies (419 subjects), and in one open label study (324 subjects). The table below describes exposure to VECTICAL Ointment in 743 subjects, including 239 exposed for 6 months and 116 exposed for one year.

Four hundred and nineteen subjects were treated with VECTICAL Ointment twice daily for 8 weeks. The population included subjects ages 13 to 87, males (284) and females (135), Caucasians (372) and non-Caucasians (47); with mild (105) to moderate (313) chronic plaque psoriasis.

Selected Adverse Events Occuring in at least 1% of Subjects in the Two Pooled Vehivle-Controlled Studies

  VECTICAL
(n = 419)
Vehicle Ointment
(n = 420)
Discomfort skin 3% 2%
Pruritus 1% 1%

Among subjects having laboratory monitoring, hypercalcemia was observed in 24% (18/74) of subjects exposed to active drug and in 16% (13/79) of subjects exposed to vehicle, however the elevations were less than 10% above the upper limit of normal [see WARNINGS AND PRECAUTIONS]

The open label study enrolled 324 subjects with psoriasis who were then treated for up to 52 weeks. Adverse events reported at a rate of greater than or equal to 3% of subjects treated with VECTICAL Ointment were lab test abnormality (8%), urine abnormality (4%), psoriasis (4%), hypercalciuria (3%), and pruritus (3%). Kidney stones were reported in 3 subjects and confirmed in two.

Postmarketing Experience

The following adverse reactions have been identified during world-wide post-approval use of VECTICAL Ointment: acute blistering dermatitis, erythema, pruritus, skin burning sensation, and skin discomfort. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Read the entire FDA prescribing information for Vectical (Calcitriol Ointment)

© Vectical Patient Information is supplied by Cerner Multum, Inc. and Vectical Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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