Slideshows Images Quizzes


Last reviewed on RxList: 3/6/2018
Veltin Side Effects Center
Acne:Causes, Solutions and Treatments for Adults

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 3/6/2018

Veltin (clindamycin phosphate and tretinoin) Gel is an antibiotic used to treat acne. Common side effects of Veltin include:

  • skin irritation
  • dryness
  • peeling
  • burning
  • redness
  • scaling
  • itching, and
  • sunburn.

The recommended dosage of Veltin is a pea-sized amount applied once daily in the evening. Erythromycin and neuromuscular blocking agents can interact with Veltin. Tell your doctor all medications you take. Do not get Veltin in your mouth, eyes, or vagina. Do not use Veltin if you have Crohn's disease, ulcerative colitis, or had colitis with past antibiotic use. If you are pregnant, talk to your doctor about using Veltin. Exercise caution if you are breastfeeding and taking Veltin.

Our Veltin (clindamycin phosphate and tretinoin) Gel Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Veltin Professional Information
Acne:Causes, Solutions and Treatments for Adults


Adverse Reactions in Clinical Studies

Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in clinical practice.

The safety data reflect exposure to VELTIN (clindamycin phosphate and tretinoin gel) Gel in 1,104 patients with acne vulgaris. Patients were 12 years or older and were treated once daily in the evening for 12 weeks. Adverse reactions that were reported in ≥ 1% of patients treated with VELTIN (clindamycin phosphate and tretinoin gel) Gel are presented in Table 1.

Table 1: Treatment-Related Adverse Reactions Reported by ≥ 1% of Subjects

  VELTIN (clindamycin phosphate and tretinoin gel) Gel
n (%)
n (%)
n (%)
Patients with at least one adverse reaction 140(13) 38(3) 141 (13) 17(3)
Application site dryness 64(6) 12(1) 62(6) 3(1)
Application site irritation 50(5) 4( < 1) 57(5) 5(1)
Application site exfoliation 50(5) 2( < 1) 56(5) 2( < 1)
Application site erythema 40(4) 6(1) 39(4) 3(1)
Application site pruritus 26(2) 7(1) 23(2) 6(1)
Sunburn 11(1) 6(1) 7(1) 3(1)
Application site dermatitis 6(1) 0(0) 8(1) 1( < 1)

Local skin reactions actively assessed at baseline and end of treatment with a score > 0 are presented in Table 2.

Table 2: VELTIN (clindamycin phosphate and tretinoin gel) GEL-Treated Patients with Local Skin Reactions

Local Reaction Baseline
End of Treatment
End of Treatment
Erythema 24% 21% 31% 35%
Scaling 8% 19% 14% 12%
Dryness 11% 22% 18% 13%
Burning 8% 13% 8% 4%
Itching 17% 15% 22% 14%

During the twelve weeks of treatment, each local skin reaction peaked at week 2 and gradually reduced thereafter.

Read the entire FDA prescribing information for Veltin (Clindamycin Phosphate and Tretinoin Gel)

Related Resources for Veltin
Acne:Causes, Solutions and Treatments for Adults

Related Health

© Veltin Patient Information is supplied by Cerner Multum, Inc. and Veltin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

Health Solutions From Our Sponsors