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Last reviewed on RxList: 1/27/2021
Verquvo Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Verquvo?

Verquvo (vericiguat) is a soluble guanylate cyclase (sGC) stimulator, indicated to reduce the risk of cardiovascular death and heart failure (HF) hospitalization following a hospitalization for heart failure or need for outpatient IV diuretics, in adults with symptomatic chronic HF and ejection fraction less than 45%.

What Are Side Effects of Verquvo?

Side effects of Verquvo include:

Dosage for Verquvo

The recommended starting dose of Verquvo is 2.5 mg orally once daily with food. Double the dose of Verquvo approximately every 2 weeks to reach the target maintenance dose of 10 mg once daily, as tolerated by the patient.

Verquvo In Children

Safety and effectiveness of Verquvo have not been established in pediatric patients.

What Drugs, Substances, or Supplements Interact with Verquvo?

Verquvo may interact with other medicines such as:

  • other soluble guanylate cyclase (sGC) stimulators and
  • PDE-5 Inhibitors

Tell your doctor all medications and supplements you use.

Verquvo During Pregnancy and Breastfeeding

Verquvo is not recommended for use during pregnancy; it may harm a fetus. The pregnancy status in females of reproductive potential should be verified prior to initiating Verquvo. Females of reproductive potential are advised to use effective contraception during treatment with Verquvo and for one month after the final dose. It is unknown if Verquvo passes into breast milk. Because of the potential for serious adverse reactions in breastfed infants from Verquvo, breastfeeding is not recommended while using Verquvo.

Additional Information

Our Verquvo (vericiguat) Tablets, For Oral Use Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Heart Disease: Symptoms, Signs, and Causes See Slideshow
Verquvo Professional Information


Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

VERQUVO was evaluated in VICTORIA, which included 2,519 patients treated with VERQUVO (up to 10 mg once daily). The mean duration of VERQUVO exposure was 1 year, and the maximum duration was 2.6 years [see Clinical Studies]. Table 1 lists adverse drug reactions occurring more commonly with VERQUVO than placebo and in ≥5% of patients treated with VERQUVO in VICTORIA.

Table 1: Adverse Drug Reactions Occurring with VERQUVO in VICTORIA

Adverse Drug ReactionVERQUVO %
N = 2,519
Placebo %
N = 2,515

Read the entire FDA prescribing information for Verquvo (Vericiguat Tablets)


In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer
Related Resources for Verquvo

© Verquvo Patient Information is supplied by Cerner Multum, Inc. and Verquvo Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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