Viberzi vs. Motegrity

Are Viberzi and Motegrity the Same Thing?

Viberzi (eluxadoline) and Motegrity (prucalopride) are used in adults to treat different symptoms associated with irritable bowel syndrome (IBS).

Viberzi is used to treat irritable bowel syndrome with diarrhea (IBS-D).

Motegrity may be used off-label to treat irritable bowel syndrome with constipation (IBS-C). It is approved to treat chronic idiopathic constipation (CIC) in adults.

Viberzi and Motegrity belong to different drug classes. Viberzi is a mu-opioid receptor agonist and Motegrity is a serotonin-4 (5-HT4) receptor agonist.

Side effects of Viberzi and Motegrity that are similar include nausea, abdominal pain, vomiting, bloating, dizziness, gas, and fatigue.

Side effects of Viberzi that are different from Motegrity include constipation, upper respiratory tract infection, runny or stuffy nose, bronchitis, and rash.

Side effects of Motegrity that are different from Viberzi include headache and diarrhea.

Viberzi may interact with cyclosporine, gemfibrozil, antiretrovirals, rifampin, eltrombopag, ciprofloxacin, gemfibrozil, fluconazole, clarithromycin, paroxetine, bupropion, alosetron, anticholinergics, opioids, rosuvastatin, alfentanil, cyclosporine, dihydroergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus, or tacrolimus.

Motegrity may interact with erythromycin and ketoconazole.

What Are Possible Side Effects of Viberzi?

Common side effects of Viberzi include:

  • constipation,
  • nausea,
  • abdominal pain,
  • upper respiratory tract infection,
  • vomiting,
  • runny or stuffy nose,
  • bloating,
  • bronchitis,
  • dizziness,
  • gas,
  • rash, and
  • fatigue.

What Are Possible Side Effects of Motegrity?

Common side effects of Motegrity include:

  • headache,
  • abdominal pain,
  • nausea,
  • diarrhea,
  • bloating,
  • dizziness,
  • vomiting,
  • gas (flatulence), and
  • fatigue

What Is Viberzi?

Viberzi (eluxadoline) is a mu-opioid receptor agonist used in adults to treat irritable bowel syndrome with diarrhea (IBS-D).

What Is Motegrity?

Motegrity (prucalopride) is a serotonin-4 (5-HT4) receptor agonist indicated for the treatment of chronic idiopathic constipation (CIC) in adults.

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow

What Drugs Interact With Viberzi?

Viberzi may interact with other irritable bowel medications, narcotic pain medicines, or heart rhythm medications.

Viberzi may also interact with cyclosporine, gemfibrozil, antiretrovirals, rifampin, eltrombopag, ciprofloxacin, fluconazole, clarithromycin, paroxetine, bupropion, anticholinergics, opioids, rosuvastatin, dihydroergotamine, ergotamine, pimozide, sirolimus, or tacrolimus.

What Drugs Interact With Motegrity?

Motegrity may interact with erythromycin or ketoconazole. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Motegrity; it is unknown how it would affect a fetus. Motegrity passes into breast milk. Consult your doctor before breastfeeding.

How Should Viberzi Be Taken?

The recommended dosage of Viberzi in adults is 100 mg twice daily, taken with food.

How Should Motegrity Be Taken?

The recommended dose of Motegrity is 2 mg once daily.

QUESTION

What is irritable bowel syndrome or IBS? See Answer
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References

Allergan. Viberzi Product Information.
www.viberzi.com/
Takeda Pharmaceutical. Motegrity Product Information.
https://www.motegrityhcp.com

Health Solutions From Our Sponsors