Vicodin

Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 10/11/2021
Vicodin Side Effects Center

Pharmacy Editor: Omudhome Ogbru, PharmD

What Is Vicodin?

Vicodin (hydrocodone/acetaminophen) is a combination of the narcotic hydrocodone and non-narcotic pain reliever acetaminophen used for the relief of moderate to moderately severe pain. Vicodin is available in generic form.

What Are Side Effects of Vicodin?

Common side effects of Vicodin include:

Tell your doctor if you have serious side effects of Vicodin including shallow breathing, slow heartbeat, fainting, confusion, fear, unusual thoughts or behavior, seizures (convulsions), upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, or yellowing of the skin or eyes (jaundice).

Dosage for Vicodin

The usual dose for adults is 1 to 2 tablets or capsules every 4 to 6 hours as needed.

What Drugs, Substances, or Supplements Interact with Vicodin?

Combining alcohol and other sedatives with hydrocodone can lead to increased sedation and even cause confusion. Combining carbamazepine with acetaminophen may increase the risk of liver toxicity.

Vicodin During Pregnancy and Breastfeeding

There are no adequate studies of hydrocodone/acetaminophen in pregnant women. Hydrocodone/acetaminophen is excreted in breast milk, and, therefore should be used cautiously by nursing mothers.

Additional Information

Our Vicodin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Medically speaking, the term "myalgia" refers to what type of pain? See Answer
Vicodin Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Call your doctor at once if you have:

  • noisy breathing, sighing, shallow breathing, breathing that stops;
  • a light-headed feeling, like you might pass out;
  • liver problems--nausea, upper stomach pain, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • low cortisol levels-- nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; o
  • high levels of serotonin in the body--agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea.

Serious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders.

Common side effects include:

  • dizziness, drowsiness, feeling tired;
  • nausea, vomiting, stomach pain;
  • constipation; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Vicodin (Hydrocodone Bitartrate and Acetaminophen)

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Vicodin Professional Information

SIDE EFFECTS

The following adverse reactions have been identified during post approval use of hydrocodone and acetaminophen tablets. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

The most frequently reported adverse reactions are light-headedness, dizziness, sedation, nausea and vomiting.

Other adverse reactions include:

Central Nervous System: Drowsiness, mental clouding, lethargy, impairment of mental and physical performance, anxiety, fear, dysphoria, psychological dependence, mood changes.

Gastrointestinal System: Constipation.

Genitourinary System: Ureteral spasm, spasm of vesical sphincters, and urinary retention.

Special Senses : Cases of hearing impairment or permanent loss have been reported predominately in patients with chronic overdose.

Dermatological: Skin rash, pruritus, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic reactions.

Hematological: Thrombocytopenia, agranulocytosis.

  • Serotonin syndrome: Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of opioids with serotonergic drugs.
  • Adrenal insufficiency: Cases of adrenal insufficiency have been reported with opioid use, more often following greater than one month of use.
  • Anaphylaxis: Anaphylaxis has been reported with ingredients contained in hydrocodone bitartrate and acetaminophen tablets.
  • Androgen deficiency: Cases of androgen deficiency have occurred with chronic use of opioids [see CLINICAL PHARMACOLOGY].

Read the entire FDA prescribing information for Vicodin (Hydrocodone Bitartrate and Acetaminophen)

© Vicodin Patient Information is supplied by Cerner Multum, Inc. and Vicodin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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