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Vigamox vs. Polymyxin B

Are Vigamox and Polymyxin B the Same Thing?

Vigamox (moxifloxacin hydrochloride ophthalmic solution) and Polymyxin B (polymyxin b sulfate) are antibiotics used to treat bacterial infections of the eyes.

Polymyxin B is also used to treat bacterial infections such as urinary tract infections (UTIs), meningitis, and blood infections.

Side effects of Vigamox and Polymyxin B that are similar include blurred vision and eye reactions (stinging, burning, redness, itching).

Side effects of Vigamox that are different from Polymyxin B include watery eyes (tearing) and eye reactions (pain, dryness, and irritation).

Side effects of Polymyxin B that are different from Vigamox include injection site reactions (pain, redness, and swelling).

Vigamox may interact with other eye medications.

Polymyxin B may interact with other drugs that can harm the kidneys or nerves (e.g., cisplatin, colistin, high-dose aspirin, aminoglycosides such as amikacin, gentamicin, tobramycin, nonsteroidal anti-inflammatory drugs-NSAIDs such as ibuprofen or naproxen).

What Are Possible Side Effects of Vigamox?

Common side effects of Vigamox include:

  • blurred vision,
  • watery eyes (tearing), and
  • eye (pain, dryness, redness, itching, burning, stinging, and irritation).

Serious side effects are not expected to occur during treatment with Vigamox. Tell your doctor if you have an unlikely but serious side effect of Vigamox such as swelling of the eye.

What Are Possible Side Effects of Polymyxin B?

Common side effects of Polymyxin B include:

  • pain,
  • redness, and
  • swelling at the injection site, or
  • temporary eye stinging/burning/redness/itchiness or
  • temporary blurred vision if used as eye drops.

Contact your doctor if you experience serious side effects of Polymyxin B including:

What Is Vigamox?

Vigamox (moxifloxacin hydrochloride ophthalmic solution) is an antibiotic used to treat bacterial infections of the eyes.

What Is Polymyxin B?

Polymyxin B (polymyxin b sulfate) is an antibiotic used to treat bacterial infections such as urinary tract infections, meningitis, blood infections, and eye infections.

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What Drugs Interact With Vigamox?

Do not use other eye drops or medications during treatment with Vigamox ophthalmic unless directed by your doctor. Other drugs may interact with Vigamox. Tell your doctor all prescription or over-the-counter medicines or supplements you use. Vigamox should be used only when prescribed during pregnancy. It is not known if this medication passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Polymyxin B?

Polymyxin B may interact with other drugs that can harm the kidneys or nerves (e.g., cisplatin, colistin, high-dose aspirin, aminoglycosides such as amikacin, gentamicin, tobramycin, nonsteroidal anti-inflammatory drugs-NSAIDs such as ibuprofen or naproxen). Tell your doctor all medications you are taking. During pregnancy, Polymyxin B should be used only when prescribed. It is unknown if this medication passes into breast milk when used in the eye. It is unlikely to harm a nursing infant. Consult your doctor before breastfeeding.

How Should Vigamox Be Taken?

The dose of Vigamox: Instill one drop in the affected eye 3 times a day for 7 days.

How Should Polymyxin B Be Taken?

Polymyxin B dose is determined by a doctor, based on the condition being treated. It may be injected into a vein, muscle, or the spinal fluid or into the area around the eye (subconjunctival sac). It can also be prepared as eye drops.

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Reviewed on 5/17/2019
References


Novartis. Vigamox Product Information.

https://www.pharma.us.novartis.com/sites/www.pharma.us.novartis.com/files/vigamox.pdf

Bedford. Polymyxin B Product Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/060716Orig1s020Lbl.pdf

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