Brand Names: Vimovo
Generic Name: esomeprazole and naproxen
- What is esomeprazole and naproxen (Vimovo)?
- What are the possible side effects of esomeprazole and naproxen (Vimovo)?
- What is the most important information I should know about esomeprazole and naproxen (Vimovo)?
- What should I discuss with my healthcare provider before taking esomeprazole and naproxen (Vimovo)?
- How should I take esomeprazole and naproxen (Vimovo)?
- What happens if I miss a dose (Vimovo)?
- What happens if I overdose (Vimovo)?
- What should I avoid while taking esomeprazole and naproxen (Vimovo)?
- What other drugs will affect esomeprazole and naproxen (Vimovo)?
- Where can I get more information (Vimovo)?
What is esomeprazole and naproxen (Vimovo)?
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Esomeprazole is a proton pump inhibitor.
Esomeprazole and naproxen is a combination medicine used to treat symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The esomeprazole in this medicine helps reduce the risk of stomach ulcers in people who may be at risk for them while receiving treatment with an NSAID.
Esomeprazole and naproxen may also be used for purposes not listed in this medication guide.
What are the possible side effects of esomeprazole and naproxen (Vimovo)?
Get emergency medical help if you have signs of an allergic reaction (hives, sneezing, runny or stuffy nose, wheezing, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Stop taking this medicine and get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.
Call your doctor at once if you have:
- severe stomach pain, diarrhea that is watery or bloody;
- bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
- heart problems-- swelling, rapid weight gain, feeling short of breath;
- kidney problems-- fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, weight gain;
- liver problems--loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes);
- low magnesium--dizziness, fast or irregular heart rate, tremors (shaking) or jerking muscle movements, feeling jittery, muscle cramps, muscle spasms in your hands and feet, cough or choking feeling;
- low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or
- new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.
Taking esomeprazole and naproxen long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk.
If you use esomeprazole and naproxen for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.
Common side effects may include:
- stomach discomfort; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about esomeprazole and naproxen (Vimovo)?
Naproxen can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Naproxen may also cause stomach or intestinal bleeding, which can be fatal.
Esomeprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine.
Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.
Esomeprazole may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.
You may be more likely to have a broken bone while taking this medicine long term or more than once per day.
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What should I discuss with my healthcare provider before taking esomeprazole and naproxen (Vimovo)?
Naproxen can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Naproxen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using naproxen, especially in older adults.
- you are also allergic to medicines like esomeprazole, such as lansoprazole, omeprazole, pantoprazole, rabeprazole, Dexilant, Nexium, Prevacid, Protonix, and others;
- you had breathing problems, kidney problems, or a severe allergic reaction after taking this medicine in the past;
- you have had an asthma attack or severe allergic reaction after taking aspirin or an NSAID; or
- you also take an HIV medicine that contains rilpivirine (Complera, Edurant, Odefsey).
Tell your doctor if you have ever had:
- heart disease, high blood pressure;
- Crohn's disease, ulcerative colitis, inflammatory bowel disease;
- stomach or intestinal bleeding after taking an NSAID;
- liver or kidney disease;
- low levels of magnesium in your blood; or
- if you smoke or drink alcohol.
You may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy.
If you are pregnant, you should not take naproxen unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
Esomeprazole and naproxen is not approved for use by anyone younger than 12 years old or weighing less than 38 kilograms (84 pounds).
How should I take esomeprazole and naproxen (Vimovo)?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take the medicine at least 30 minutes before a meal. Use the lowest dose that is effective in treating your condition.
Swallow the tablet whole and do not crush, chew, or break it.
Esomeprazole and naproxen can affect the results of certain medical tests. Tell any doctor who treats you that you are using this medicine.
Store at room temperature away from moisture, heat, and light.
What happens if I miss a dose (Vimovo)?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose (Vimovo)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include drowsiness, severe weakness, stomach pain, or vomiting.
What should I avoid while taking esomeprazole and naproxen (Vimovo)?
This medicine can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.
Avoid drinking alcohol. It may increase your risk of stomach bleeding.
Taking regular naproxen together with esomeprazole (Nexium) will not work the same way as taking combination esomeprazole and naproxen (Vimovo). Do not substitute this medicine with over-the-counter products.
Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to naproxen (such as aspirin, ibuprofen, or ketoprofen).
What other drugs will affect esomeprazole and naproxen (Vimovo)?
Ask your doctor before using esomeprazole and naproxen if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.
Tell your doctor about all your current medicines. Many drugs can affect esomeprazole and naproxen, especially:
- St. John's wort;
- a blood thinner such as warfarin (Coumadin, Jantoven);
- a diuretic or "water pill";
- heart or blood pressure medication; or
- steroid medicine such as prednisone or methylprednisolone.
This list is not complete and many other drugs may affect esomeprazole and naproxen. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Where can I get more information (Vimovo)?
Your pharmacist can provide more information about esomeprazole and naproxen.
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