Slideshows Images Quizzes


Last reviewed on RxList: 12/9/2008
Viokase Side Effects Center

Last reviewed on RxList 1/3/2016

Viokase (pancrelipase) is a combination of three enzymes (proteins) normally produced by the pancreas used to replace enzymes (lipase, protease, and amylase) when the body does not have enough of its own. Certain medical conditions can cause this lack of enzymes, including cystic fibrosis, chronic inflammation of the pancreas, or blockage of the pancreatic ducts. Viokase may also be used following surgical removal of the pancreas. Viokase is available in generic form. Common side effects of Viokase include diarrhea, constipation, abdominal pain, abdominal cramps, stomach pain or upset, nausea, vomiting, bloating, gas, greasy stools, rectal irritation, headache, dizziness, cough, or weight loss.

Dosage of Viokase powder for patients with cystic fibrosis is 1/4 tsp (0.7 g) with meals. Dosage of Viokase tablets for patients with cystic fibrosis or chronic pancreatitis ranges from 8,000 to 32,000 Lipase USP Units taken with meals, i.e., one to four Viokase 8 tablets, or one to two Viokase 16 tablets with meals or as directed by a physician. Other drugs may interact with Viokase. Tell your doctor all prescription and over-the-counter medications and supplements you use. During pregnancy, Viokase should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Viokase (pancrelipase) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Viokase Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have severe or unusual stomach pain. This could be a symptom of a rare but serious bowel disorder.

Less serious side effects may include:

  • nausea or vomiting;
  • mild stomach pain or upset;
  • diarrhea or constipation;
  • bloating or gas;
  • greasy stools;
  • rectal irritation;
  • headache, dizziness;
  • cough; or
  • weight loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Viokase (Pancrelipase Tablets, Powder)

Viokase Professional Information


The dust or finely powdered pancreatic enzyme concentrate is irritating to the nasal mucosa and the respiratory tract. It has been documented that inhalation of the airborne powder can precipitate an asthma attack. The literature also contains several references to asthma due to inhalation in patients sensitized to pancreatic enzyme concentrates. Extremely high doses of exogenous pancreatic enzymes have been associated with hyperuricemia and hyperuricosuria. Overdosage of pancreatic enzyme concentrate may cause diarrhea or transient intestinal upset.

Read the entire FDA prescribing information for Viokase (Pancrelipase Tablets, Powder)

Related Resources for Viokase

Related Drugs

© Viokase Patient Information is supplied by Cerner Multum, Inc. and Viokase Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

Health Solutions From Our Sponsors