Last updated on RxList: 6/4/2019
Viorele Side Effects Center

Last reviewed on RxList 6/4/2019

Viorele (desogestrel and ethinyl estradiol, and ethinyl estradiol) is a combination of female hormones indicated for the prevention of pregnancy in women who elect to use this combination product as a method of contraception. Viorele is available as a generic. Common side effects of Viorele include:

  • nausea and vomiting (especially within the first few months of taking Viorele),
  • stomach cramps,
  • bleeding between menstrual periods,
  • weight gain,
  • breast tenderness,
  • bloating,
  • headache,
  • acne,
  • dizziness, and
  • difficulty wearing contact lenses.

Cigarette smoking increases the risk of serious cardiovascular side effects from oral contraceptive use, especially in women over 35 years of age and who smoke more than 15 cigarettes per day. Women who use oral contraceptives are strongly advised not to smoke.

Viorele tablets come in packets containing tablets of variable strengths; desogestrel and ethinyl estradiol tablets strengths of 0.15 mg/0.02 mg and ethinyl estradiol Tablets at 0.01 mg strength. To achieve maximum contraceptive effectiveness, Viorele must be taken exactly as directed and at intervals not exceeding 24 hours. Viorele may interact with rifampin, barbiturates, phenylbutazone, phenytoin sodium, carbamazepine, griseofulvin, ampicillin, tetracycline antibiotics, and lamotrigine. Tell your doctor all medications and supplements you use. Viorele is not recommended for use during pregnancy. Viorele passes into breast milk and may cause adverse effects on a nursing baby. Viorele may also decrease the quantity and quality of breast milk. Breastfeeding while using Viorele is not recommended.

Our Viorele Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Which of the following are methods for contraception? See Answer
Viorele Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using birth control pills and call your doctor at once if you have:

  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • liver problems--loss of appetite, upper stomach pain, tiredness, fever, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • increased blood pressure--severe headache, blurred vision, pounding in your neck or ears;
  • swelling in your hands, ankles, or feet;
  • changes in the pattern or severity of migraine headaches;
  • a breast lump; or
  • symptoms of depression--sleep problems, weakness, tired feeling, mood changes.

Common side effects may include:

  • nausea, vomiting (especially when you first start taking this medicine);
  • breast tenderness;
  • breakthrough bleeding;
  • acne, darkening of facial skin;
  • weight gain; or
  • problems with contact lenses.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Viorele (Deogestrel and Ethinyl Estradiol Tablets)


Choosing Your Birth Control Method See Slideshow
Viorele Professional Information


An increased risk of the following serious adverse reactions has been associated with the use of oral contraceptives (see WARNINGS section):

There is evidence of an association between the following conditions and the use of oral contraceptives:

  • Mesenteric thrombosis
  • Retinal thrombosis

The following adverse reactions have been reported in patients receiving oral contraceptives and are believed to be drug-related:

The following adverse reactions have been reported in users of oral contraceptives and the association has been neither confirmed nor refuted:

Read the entire FDA prescribing information for Viorele (Deogestrel and Ethinyl Estradiol Tablets)

© Viorele Patient Information is supplied by Cerner Multum, Inc. and Viorele Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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