Vitrakvi

Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 11/2/2021
Vitrakvi Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Vitrakvi?

Vitrakvi (larotrectinib) is a kinase inhibitor indicated for the treatment of adult and pediatric patients with solid tumors that have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion without a known acquired resistance mutation, are metastatic or where surgical resection is likely to result in severe morbidity, and have no satisfactory alternative treatments or that have progressed following treatment.

What Are Side Effects of Vitrakvi?

Common side effects of Vitrakvi include:

Dosage for Vitrakvi

The recommended dosage of Vitrakvi in adult and pediatric patients with a body surface area of at least 1.0 meter-squared is 100 mg orally twice daily. The recommended dosage of Vitrakvi in in pediatric patients with body surface area of less than 1.0 meter-squared is 100 mg/m2 orally twice daily.

What Drugs, Substances, or Supplements Interact with Vitrakvi?

Vitrakvi may interact with strong CYP3A4 inhibitors including grapefruit or grapefruit juice, strong CYP3A4 inducers including St. John's wort, and sensitive CYP3A4 substrates. Tell your doctor all medications and supplements you use.

Vitrakvi During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Vitrakvi; it may harm a fetus. Breastfeeding is not recommended while using Vitrakvi and for 1 week after the final dose.

Additional Information

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Our Vitrakvi (larotrectinib) Capsules, for Oral Use, and Oral Solution Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Vitrakvi Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe or ongoing stomach pain, vomiting, or diarrhea;
  • confusion, memory problems, severe dizziness;
  • problems with speech or coordination;
  • numbness, tingling, or burning pain in your hands or feet;
  • fever, flu symptoms, sore throat, cough;
  • sores or ulcers in your mouth or on your skin;
  • unusual tiredness, feeling light-headed or short of breath;
  • pale skin, cold hands and feet;
  • pain, warmth, redness, or swelling under your skin; or
  • liver problems--loss of appetite, stomach pain (upper right side), nausea, vomiting, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • nausea, vomiting, diarrhea, constipation;
  • cough;
  • dizziness;
  • tiredness; or
  • abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Vitrakvi (Larotrectinib Capsules)

Vitrakvi Professional Information

Read the entire FDA prescribing information for Vitrakvi (Larotrectinib Capsules)

© Vitrakvi Patient Information is supplied by Cerner Multum, Inc. and Vitrakvi Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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