Vitrase Side Effects Center

Last updated on RxList: 8/22/2022
Vitrase Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Vitrase?

Vitrase (hyaluronidase injection) is a genetically designed protein indicated to enhance the absorption and dispersion of other injected drugs.

What Are Side Effects of Vitrase?

Common side effects of Vitrase include:

  • local injection site reactions such as pain, itching, redness, or swelling.
  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • chills,
  • fast or irregular heartbeat,
  • lightheadedness,
  • loss of coordination,
  • nausea,
  • vomiting, and
  • swelling at the site where the injection was given

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Vitrase

The dose of Vitrase is determined by a physician. Vitrase should not be should not be injected into or around an infected or acutely inflamed area because of the danger of spreading a localized infection. No adequate and well controlled animal studies have been conducted with Vitrase to determine reproductive effects.

What Drugs, Substances, or Supplements Interact with Vitrase?

Vitrase may interact with furosemide, phenytoin, sedatives, anxiety medications, aspirin or salicylates, cortisone or ACTH, estrogens, or antihistamines (such as cold or allergy medicines). Tell your doctor all medications and supplements you use.

Vitrase During Pregnancy or Breastfeeding

No adequate and well-controlled studies have been conducted with Vitrase in pregnant women. Vitrase should be used during pregnancy only if clearly needed. It is not known whether Vitrase is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Vitrase is administered to a nursing woman.

Additional Information

Our Vitrase Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Vitrase Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • swelling in your hands, feet, or other body areas; or
  • pain, swelling, itching, or redness where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Vitrase Professional Information


The following adverse reactions have been identified during post-approval use of hyaluronidase products. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The most frequently reported adverse reactions have been local injection site reactions.

Hyaluronidase has been reported to enhance the adverse reactions associated with co-administered drug products. Edema has been reported most frequently in association with hypodermoclysis.

Allergic reactions (urticariaangioedema) have been reported in less than 0.1% of patients receiving hyaluronidase. Anaphylactic-like reactions following retrobulbar block or intravenous injections have occurred, rarely.

Read the entire FDA prescribing information for Vitrase (Hyaluronidase Injection)

© Vitrase Patient Information is supplied by Cerner Multum, Inc. and Vitrase Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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