Medical Editor: John P. Cunha, DO, FACOEP
What Is Vivotif?
Vivotif Oral (typhoid vaccine) is a "live" immunization used to help prevent infection (typhoid fever) caused by the bacteria Salmonella typhi. Vivotif Oral is recommended for people older than 6 years who are traveling to areas where typhoid fever is common (i.e., Central and South America, Africa, Asia), who are exposed to someone with typhoid infection, or who work with the bacteria in a laboratory.
What Are Side Effects of Vivotif?
Common side effects of Vivotif Oral include:
Becoming infected with typhoid fever is much more dangerous to your health than receiving Vivotif Oral vaccine. However, like any medicine, Vivotif Oral vaccine can cause side effects but the risk of serious side effects is extremely low.
Dosage for Vivotif
The complete immunization schedule for adults and children above 6 years of age is the ingestion of one Vivotif Oral capsule on each of days 1, 3 and 5. Before receiving Vivotif Oral vaccine, tell the doctor all other vaccines you have recently received.
What Drugs, Substances, or Supplements Interact with Vivotif?
Vivotif Oral may interact with proguanil (Malarone). Other drugs may affect this vaccine. Tell your doctor all prescription and over-the-counter medications you use.
Vivotif During Pregnancy and Breastfeeding
During pregnancy, Vivotif Oral vaccine should be used only when prescribed. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.
Our Vivotif Oral (typhoid vaccine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Becoming infected with typhoid fever is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.
Common side effects include:
- nausea, vomiting, diarrhea, stomach pain; or
- skin rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.
Read the entire detailed patient monograph for Vivotif (Typhoid Vaccine)
More than 1.4 million doses of Ty21a have been administered in controlled clinical trials and more than 150 million doses of Vivotif (Typhoid Vaccine Live Oral Ty21a) have been marketed world-wide. Active surveillance for adverse reactions of enteric-coated capsules was performed in a pilot study (21) and in a subgroup of a large field trial (14) involving a total of 483 individuals receiving 3 vaccine doses. The overall symptom rates from both studies when vaccinated with capsules were combined and shown to be: abdominal pain (6.4%), nausea (5.8%), headache (4.8%), fever (3.3%), diarrhea (2.9%), vomiting (1.5%) and skin rash (1.0%). Only the incidence of nausea occurred at a statistically higher frequency in the vaccinated group as compared to the placebo group (14). Administration of vaccine doses more than 5- fold higher than the currently recommended dose caused only mild reactions in an open study involving 155 healthy adult males (16).
Post-marketing surveillance has revealed that adverse reactions are infrequent and mild (17). Adverse reactions reported to the manufacturer during 1991–1995, during which time over 60 million doses (capsules) were administered, included: diarrhea (N = 45), abdominal pain (N = 42), nausea (N = 35), fever (N = 34), headache (N = 26), skin rash (N = 26), vomiting (N = 18), or urticaria in the trunk and/or extremities (N = 13). One isolated, non-fatal anaphylactic shock considered to be an allergic reaction to the vaccine was reported.
To report SUSPECTED ADVERSE REACTIONS, contact PaxVax, Inc. at 1-800-533-5899 http://www.paxvax.com; or contact the Vaccine Adverse Event Reporting System (VAERS) at 1-800- 822-7967 or http://www.fda.gov/vaers
Read the entire FDA prescribing information for Vivotif (Typhoid Vaccine)
© Vivotif Patient Information is supplied by Cerner Multum, Inc. and Vivotif Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.
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