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Voltaren XR

Last reviewed on RxList: 1/25/2017
Voltaren XR Side Effects Center

Last reviewed on RxList 12/1/2016

Voltaren XR (diclofenac) is an extended release nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of pain, fever, and inflammation by reducing the production of prostaglandins. Voltaren RX is used primarily for the treatment of inflammation and pain caused by conditions such as rheumatoid arthritis and osteoarthritis. Common side effects of Voltaren XR include:

  • upset stomach,
  • heartburn,
  • indigestion,
  • stomach pain,
  • nausea,
  • vomiting,
  • diarrhea,
  • constipation,
  • bloating,
  • gas,
  • dizziness,
  • drowsiness,
  • headache,
  • nervousness,
  • skin itching or rash,
  • stuffy nose,
  • sweating,
  • blurred vision,
  • swelling or pain in your arms or legs, or
  • ringing in your ears.

Tell your doctor if you have unlikely but serious side effects of Voltaren XR including:

  • sudden or unexplained weight gain,
  • hearing changes,
  • mental/mood changes,
  • difficult or painful swallowing, or
  • unusual tiredness.

The usual recommended dosage of Voltaren XR is 100 mg once daily. Voltaren RX should be taken with food to reduce stomach upset. Potential drug interactions include lithium (Eskalith, Lithobid), blood pressure medications, methotrexate (Rheumatrex, Trexall), certain antibiotics, and anticoagulants. Like other NSAIDs, Voltaren XR is generally avoided during pregnancy because it may affect the cardiovascular system of the fetus. It is not known whether Voltaren XR is excreted in breast milk. Consult your doctor before breastfeeding.  

Our Voltaren XR Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Voltaren XR Consumer Information

Get emergency medical help if you have signs of an allergic reaction: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

Stop using diclofenac and call your doctor at once if you have:

  • the first sign of any skin rash, no matter how mild;
  • shortness of breath (even with mild exertion);
  • swelling or rapid weight gain;
  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • liver problems--nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • kidney problems--little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;
  • high blood pressure--severe headache, pounding in your neck or ears, nosebleed, anxiety, confusion;
  • low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or
  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • indigestion, gas, stomach pain, nausea, vomiting;
  • diarrhea, constipation;
  • headache, dizziness, drowsiness;
  • stuffy nose;
  • itching, increased sweating;
  • increased blood pressure; or
  • swelling or pain in your arms or legs.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Voltaren XR (Diclofenac Sodium Extended-Release Tablets)

Voltaren XR Professional Information

SIDE EFFECTS

In patients taking Voltaren®-XR (diclofenac sodium extended-release) tablets, USP or other NSAIDs, the most frequently reported adverse experiences occurring in approximately 1%-10% of patients are:

Gastrointestinal experiences including: abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, GI ulcers (gastric/duodenal) and vomiting.

Abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, headaches, increased bleeding time, pruritus, rashes and tinnitus.

Additional adverse experiences reported occasionally include:

Body as a Whole: fever, infection, sepsis

Cardiovascular System: congestive heart failure, hypertension, tachycardia, syncope

Digestive System: dry mouth, esophagitis, gastric/peptic ulcers, gastritis, gastrointestinal bleeding, glossitis, hematemesis, hepatitis, jaundice

Hemic and Lymphatic System: ecchymosis, eosinophilia, leukopenia, melena, purpura, rectal bleeding, stomatitis, thrombocytopenia

Metabolic and Nutritional: weight changes

Nervous System: anxiety, asthenia, confusion, depression, dream abnormalities, drowsiness, insomnia, malaise, nervousness, paresthesia, somnolence, tremors, vertigo

Respiratory System: asthma, dyspnea

Skin and Appendages: alopecia, photosensitivity, sweating increased

Special Senses: blurred vision

Urogenital System: cystitis, dysuria, hematuria, interstitial nephritis, oliguria/polyuria, proteinuria, renal failure.

Other adverse reactions, which occur rarely are

Body as a Whole: anaphylactic reactions, appetite changes, death

Cardiovascular System: arrhythmia, hypotension, myocardial infarction, palpitations, vasculitis

Digestive System: colitis, eructation, fulminant hepatitis with and without jaundice, liver failure, liver necrosis, pancreatitis

Hemic and Lymphatic System: agranulocytosis, hemolytic anemia, aplastic anemia, lymphadenopathy, pancytopenia

Metabolic and Nutritional: hyperglycemia

Nervous System: convulsions, coma, hallucinations, meningitis

Respiratory System: respiratory depression, pneumonia

Skin and Appendages: angioedema, toxic epidermal necrolysis, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, urticaria

Special Senses: conjunctivitis, hearing impairment.

Read the entire FDA prescribing information for Voltaren XR (Diclofenac Sodium Extended-Release Tablets)

Related Resources for Voltaren XR

Read the Voltaren XR User Reviews »

© Voltaren XR Patient Information is supplied by Cerner Multum, Inc. and Voltaren XR Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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