Vraylar vs. Risperdal

Vraylar (cariprazine) and Risperdal (risperidone) are atypical antipsychotics indicated for the treatment of schizophrenia and bipolar mania.

Vraylar is also used to treat mixed episodes associated with bipolar I disorder.

Risperdal is also used to treat autism.

Side effects of Vraylar and Risperdal that are similar include extrapyramidal symptoms (muscle spasms, muscle rigidity, tremor, jerking movements), nausea, vomiting, sleepiness/drowsiness, restlessness, weight gain, headache, sleep problems (insomnia), abdominal/stomach pain, constipation, anxiety, dry mouth, dizziness, and cough.

Side effects of Vraylar that are different from Risperdal include agitation, indigestion, toothache, diarrhea, pain in the extremities, loss of appetite, and back pain.

Side effects of Risperdal that are different from Vraylar include tiredness, fatigue, fever, feeling hot or cold, increased appetite, sore throat, runny or stuffy nose, and skin rash.

Both Vraylar and Risperdal may interact with CYP3A4 inducers (such as rifampin carbamazepine).

Vraylar may also interact with CYP3A4 inhibitors (such as itraconazole and ketoconazole).

Risperdal may also interact with other medicines that make you sleepy (such as cold or allergy medicines, narcotics, sleeping pills, muscle relaxers, and medicines for seizures, depression, or anxiety), cimetidine, ranitidine, clozapine, phenobarbital, and medicines used to treat Parkinson's disease.

Side effects of Vraylar include:

• extrapyramidal symptoms (muscle spasms, muscle rigidity, tremor, jerking movements),
• agitation,
• indigestion,
• nausea,
• vomiting,
• sleepiness,
• restlessness,
• weight gain,
• headache,
• insomnia,
• abdominal pain,
• constipation,
• toothache,
• anxiety,
• diarrhea,
• pain in the extremities,
• dry mouth,
• loss of appetite,
• back pain,
• dizziness, and
• cough.

Common side effects of Risperdal include:

• extrapyramidal effects (sudden, often jerky, involuntary motions of the head, neck, arms, body, or eyes),
• dizziness,
• tiredness,
• drowsiness,
• fatigue,
• fever,
• weight gain,
• feeling hot or cold,
• headache,
• dry mouth,
• increased appetite,
• restlessness,
• anxiety,
• sleep problems (insomnia),
• nausea,
• vomiting,
• stomach pain,
• constipation,
• cough,
• sore throat,
• runny or stuffy nose,
• or skin rash.

Tell your doctor if you experience serious side effects of Risperdal including difficulty swallowing, muscle spasms, shaking (tremor), mental/mood changes, or signs of infection (such as fever, persistent sore throat).

Vraylar (cariprazine) is an atypical antipsychotic indicated for the treatment of schizophrenia, and the acute treatment of manic or mixed episodes associated with bipolar I disorder.

Risperdal (risperidone) is an atypical antipsychotic prescribed to treat:

• schizophrenia,
• bipolar mania,
• and autism.

Vraylar may interact with CYP3A4 inducers and inhibitors. Tell your doctor all medications and supplements you use.

Risperdal may interact with other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety), carbamazepine, fluoxetine, paroxetine, phenytoin, phenobarbital, or rifampin.

The starting dose of Vraylar is 1.5 mg once daily.

Risperdal dose ranges from 0.5 mg to 8mg/day.