Vumerity vs. Aubagio

Are Vumerity and Aubagio the Same Thing?

Vumerity (diroximel fumarate) and Aubagio (teriflunomide) are used to treat relapsing forms of multiple sclerosis (MS).

Vumerity and Aubagio belong to different drug classes. Vumerity is an immunomodulator and Aubagio is a pyrimidine synthesis inhibitor.

Side effects of Vumerity and Aubagio that are similar include diarrhea and nausea.

Side effects of Vumerity that are different from Aubagio include flushing, abdominal pain, vomiting, itching, rash, albumin in the urine, redness, and indigestion/heartburn.

Side effects of Aubagio that are different from Vumerity include liver problems, influenza, hair loss or thinning hair, burning or prickly feeling in your skin, and numbness or tingling in your hands or feet that is different from your MS symptoms.

Vumerity may interact with dimethyl fumarate.

Aubagio may interact with "live" vaccines, cholestyramine, methotrexate, rifampin, warfarin, birth control pills or hormone replacement therapy, cancer medicines, medicine to treat autoimmune disorders (such as rheumatoid arthritis, lupus, or psoriasis), medicines to prevent organ transplant rejection, cholesterol-lowering medications, and steroids.

What Are Possible Side Effects of Vumerity?

Common side effects of Vumerity include:

  • flushing,
  • abdominal pain,
  • diarrhea,
  • nausea,
  • vomiting,
  • itching,
  • rash,
  • albumin in the urine,
  • redness, and
  • indigestion/heartburn

What Are Possible Side Effects of Aubagio?

Common side effects of Aubagio include:

  • liver problems,
  • influenza,
  • hair loss or thinning hair,
  • nausea,
  • diarrhea,
  • burning or prickly feeling in your skin, or
  • numbness or tingling in your hands or feet that is different from your MS symptoms.

Tell your doctor if you have serious side effects of Aubagio including:

  • fever,
  • chills,
  • body aches,
  • flu symptoms,
  • sores in your mouth and throat,
  • itching,
  • tired feeling,
  • loss of appetite,
  • dark urine,
  • clay-colored stools,
  • yellowing of the skin or eyes,
  • fast or racing heartbeats,
  • confusion,
  • little or no urinating,
  • chest pain,
  • dry cough,
  • wheezing,
  • feeling short of breath,
  • skin redness or peeling,
  • swelling,
  • rapid weight gain, or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

What Is Vumerity?

Vumerity (diroximel fumarate) is an immunomodulator indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

What Is Aubagio?

Aubagio (teriflunomide) is a pyrimidine synthesis inhibitor used to treat relapsing forms of multiple sclerosis (MS).


What Is Multiple Sclerosis? MS Symptoms, Causes, Diagnosis See Slideshow

What Drugs Interact With Vumerity?

Vumerity may interact with other medicines such as:

  • dimethyl fumarate

Tell your doctor all medications and supplements you use.

What Drugs Interact With Aubagio?

Aubagio may increase exposure of ethinyl estradiol and levonorgestrel. Patients taking Coumadin (warfarin) should be closely monitored as interactions may occur. Aubagio may cause major birth defects if used during pregnancy. Pregnancy must be excluded before starting treatment with Aubagio. Pregnancy must be avoided while taking Aubagio treat relapsing forms of multiple sclerosis (MS). If Aubagio is used during pregnancy, or if the patient becomes pregnant while taking Aubagio, the drug should be discontinued immediately and an accelerated elimination procedure should be initiated. Consult your doctor before breastfeeding.

How Should Vumerity Be Taken?

The starting dose of Vumerity is 231 mg twice a day, orally, for 7 days. The maintenance dose of Vumerity after 7 days is 462 mg (administered as two 231 mg capsules) twice a day, orally.

How Should Aubagio Be Taken?

The recommended dose for Aubagio is 7 mg or 14 mg taken orally, once daily, with or without food.


What kind of disease is multiple sclerosis? See Answer

All drug information provided on is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, makes every effort to update its drug information. Due to the time-sensitive nature of drug information, makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the or websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

Biogen. Vumerity Product Information.

Genzyme. Aubagio Product Information

Health Solutions From Our Sponsors