Last updated on RxList: 9/4/2019
Vyfemla Side Effects Center

Last reviewed on RxList 9/4/2019

Vyfemla (norethindrone and ethinyl estradiol tablets) is an oral contraceptive indicated for the prevention of pregnancy in women who elect to use this product as a method of contraception. Vyfemla is available in generic form. Common side effects of Vyfemla include:

. Cigarette smoking increases the risk of serious cardiovascular side effects from use of oral contraceptives such as Vyfemla. Women who use oral contraceptives including Vyfemla are strongly advised not to smoke.

The dose of Vyfemla is one pill at the same time every day until the pack is empty. If a woman is on the 28-day regimen, she should start the next pack the day after the last inactive tablet and not wait any days between packs. Vyfemla may interact with:

Tell your doctor all medications and supplements you use. Vyfemla is not recommended for use during pregnancy. Small amounts of Vyfemla pass into breast milk and may cause adverse reactions in nursing infants. Breastfeeding while using Vyfemla is not recommended.

Our Vyfemla (norethindrone and ethinyl estradiol tablets) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Vyfemla Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • liver problems--loss of appetite, upper stomach pain, tiredness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • increased blood pressure--severe headache, blurred vision, pounding in your neck or ears;
  • swelling in your hands, ankles, or feet;
  • a change in the pattern or severity of migraine headaches;
  • a breast lump; or
  • symptoms of depression--sleep problems, weakness, tired feeling, mood changes.

Common side effects may include:

  • nausea, vomiting;
  • breast tenderness;
  • breakthrough bleeding;
  • headache; or
  • problems with contact lenses.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Vyfemla (Norethindrone and Ethinyl Estradiol Tablets)


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Vyfemla Professional Information


An increased risk of the following serious adverse reactions has been associated with the use of oral contraceptives [see WARNINGS section]:

There is evidence of an association between the following conditions and the use of oral contraceptives, although additional confirmatory studies are needed:

  • Mesenteric thrombosis
  • Retinal thrombosis

The following adverse reactions have been reported in patients receiving oral contraceptives and are believed to be drug-related:

  • Nausea
  • Vomiting

Gastrointestinal symptoms (such as abdominal cramps and bloating)

  • Breakthrough bleeding
  • Spotting
  • Change in menstrual flow
  • Amenorrhea
  • Temporary infertility after discontinuation of treatment
  • Edema
  • Melasma which may persist
  • Breast changes: tenderness, enlargement, and secretion
  • Change in weight (increase or decrease)
  • Change in cervical ectropion and secretion
  • Possible diminution in lactation when given immediately postpartum
  • Cholestatic jaundice
  • Migraine
  • Rash (allergic)
  • Mental depression
  • Reduced tolerance to carbohydrates
  • Vaginal candidiasis
  • Change in corneal curvature (steepening)
  • Intolerance to contact lenses

The following adverse reactions have been reported in users of oral contraceptives, and the association has been neither confirmed nor refuted:

Read the entire FDA prescribing information for Vyfemla (Norethindrone and Ethinyl Estradiol Tablets)

© Vyfemla Patient Information is supplied by Cerner Multum, Inc. and Vyfemla Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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