Wakix vs. Sunosi

Are Wakix and Sunosi the Same Thing?

Wakix (pitolisant) and Sunosi (solriamfetol) are used to treat excessive daytime sleepiness (EDS) in adult patients with narcolepsy.

Sunosi is also used to improve wakefulness in adult patients with obstructive sleep apnea (OSA).

Wakix and Sunosi belong to different drug classes. Wakix is a histamine-3 (H3) receptor antagonist/inverse agonist and Sunosi is a dopamine and norepinephrine reuptake inhibitor (DNRI).

Side effects of Wakix and Sunosi that are similar include insomnia, nausea, and anxiety.

Side effects of Sunosi that are different from Wakix include headache and decreased appetite.

Wakix may interact with antidepressants, seizure medications, rifampin, antihistamines, antiarrhythmics, some antibiotics, hormonal contraceptives, midazolam, and cyclosporine.

Sunosi may interact with monoamine oxidase inhibitors (MAOIs), other drugs that increase blood pressure and/or heart rate, and dopaminergic drugs.

Sunosi may interact with other drugs.

What Are Possible Side Effects of Wakix?

Common side effects of Wakix include:

  • insomnia,
  • nausea, and
  • anxiety

Tell your doctor all medications and supplements you use.

What Are Possible Side Effects of Sunosi?

  • headache,
  • nausea,
  • decreased appetite,
  • insomnia, and
  • anxiety

What is Wakix?

Wakix (pitolisant) is a histamine-3 (H3) receptor antagonist/inverse agonist indicated for the treatment of excessive daytime sleepiness (EDS) in adult patients with narcolepsy.

What is Sunosi?

Sunosi (solriamfetol) is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated to improve wakefulness in adult patients with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea (OSA).

What Drugs Interact With Wakix?

Wakix may interact with:

  • certain antidepressants,
  • seizure medications,
  • rifampin,
  • antihistamines,
  • antiarrhythmics,
  • hormonal contraceptives,
  • midazolam, and
  • cyclosporine

Tell your doctor all medications and supplements you use.

SLIDESHOW

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What Drugs Interact With Sunosi?

Sunosi may interact with monoamine oxidase inhibitors (MAOIs), other drugs that increase blood pressure and/or heart rate, and dopaminergic drugs. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Sunosi; it is unknown how it would affect a fetus. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to Sunosi during pregnancy. It is unknown if Sunosi passes into breast milk. Consult your doctor before breastfeeding.

How Should Wakix be Taken?

The recommended dosage range for Wakix is 17.8 mg to 35.6 mg daily.

How Should Sunosi be Taken?

Sunosi is administered once daily upon awakening. The starting dose of Sunosi for patients with narcolepsy is 75 mg once daily. The starting dose of Sunosi for patients with OSA is 37.5 mg once daily.

Disclaimer

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References
Harmony Biosciences. Wakix Product Information.

https://wakix.com/

Jazz Pharmaceuticals Inc. Sunosi Product Information.

https://www.sunosi.com

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