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Wellbutrin vs. Zoloft

Are Wellbutrin and Zoloft the Same Thing?

Wellbutrin (bupropion) and Zoloft (sertraline) are antidepressants used for the management of major depression. Wellbutrin is also used to treat seasonal affective disorder.

Zoloft is also used to treat obsessive-compulsive disorder (OCD), panic disorder, posttraumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD).

The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects.

Wellbutrin and Zoloft are different types of antidepressants. Wellbutrin is an aminoketone and Zoloft is a selective serotonin reuptake inhibitor (SSRI).

What Are Possible Side Effects of Wellbutrin?

Common side effects of Wellbutrin include:

What Are Possible Side Effects of Zoloft?

Common side effects of Zoloft include:

  • sleepiness
  • drowsiness
  • tired feeling
  • nervousness
  • sleep problems (insomnia)
  • dizziness
  • nausea
  • skin rash
  • headache
  • diarrhea
  • constipation
  • upset stomach
  • stomach pain
  • dry mouth
  • changes in appetite
  • abnormal ejaculation
  • impotence
  • decreased sex drive
  • difficulty having an orgasm
  • dry mouth, and
  • weight loss.

Tell your doctor if you have serious side effects of Zoloft including:

  • very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, feeling like you might pass out;
  • agitation, hallucinations, fever, overactive reflexes, tremors;
  • nausea, vomiting, loss of appetite, feeling unsteady, loss of coordination;
  • trouble concentrating, memory problems, weakness, fainting, seizure, shallow breathing, or breathing that stops.

What Is Wellbutrin?

Wellbutrin is a prescription medicine used to treat adults with a certain type of depression called major depressive disorder.

Talk to your healthcare provider if you do not think that your condition is getting better with Wellbutrin treatment.

What Is Zoloft?

Zoloft (sertraline) is an SSRI (selective serotonin reuptake inhibitors) antidepressant prescribed for the treatment of depression, obsessive compulsive disorder (OCD), panic disorder, posttraumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD).

SLIDESHOW

Learn to Spot Depression: Symptoms, Warning Signs, Medication See Slideshow

What Drugs Interact With Wellbutrin?

Do not take Wellbutrin if you:

  • have or had a seizure disorder or epilepsy.
  • are taking Zyban (used to help people stop smoking) or any other medicines that contain bupropion hydrochloride, such as Wellbutrin SR Sustained-Release Tablets or Wellbutrin XL Extended-Release Tablets. Bupropion is the same ingredient that is in Wellbutrin.
  • drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy) or benzodiazepines and you stop using them all of a sudden.
  • have taken within the last 14 days medicine for depression called a monoamine oxidase inhibitor (MAOI), such as Nardil (phenelzine sulfate), Parnate (tranylcypromine sulfate), or Marplan (isocarboxazid).
  • have or had an eating disorder such as anorexia nervosa or bulimia.
  • are allergic to the active ingredient in Wellbutrin, bupropion, or to any of the inactive ingredients. See the end of this leaflet for a complete list of ingredients in Wellbutrin.

What Drugs Interact With Zoloft?

Zoloft may interact with cold or allergy medicines, sedatives, narcotics, sleeping pills, muscle relaxers, medicines for seizures or anxiety, other antidepressants, nonsteroidal anti-inflammatory drugs (NSAIDs), blood thinners, cimetidine, fentanyl, St. John's wort, tramadol, L-tryptophan, heart medications, or migraine headache medicines.

Zoloft may also interact with digoxin, linezolid, lithium, or valproate.

Do not take Zoloft if you:

  • take a monoamine oxidase inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid.
  • have taken an MAOI within 2 weeks of stopping Zoloft unless directed to do so by your healthcare provider.
  • have stopped taking an MAOI in the last 2 weeks unless directed to do so by your healthcare provider.
  • take any other medicines that contain sertraline (such as sertraline HCl or sertraline hydrochloride).
  • take the antipsychotic medicine pimozide (Orap®) because this can cause serious heart problems.
  • are allergic to sertraline or any of the ingredients in Zoloft. See the end of this Medication Guide for a complete list of ingredients in Zoloft.
  • take Antabuse® (disulfiram) (if you are taking the liquid form of Zoloft) due to the alcohol content.

If Zoloft is discontinued abruptly, withdrawal side effects may include abdominal cramps, flu-like symptoms, fatigue, and memory impairment.

How Should Wellbutrin Be Taken?

Take Wellbutrin exactly as prescribed by your doctor.

  • Take Wellbutrin at the same time each day.
  • Take your doses of Wellbutrin at least 6 hours apart.
  • You may take Wellbutrin with or without food.
  • If you miss a dose, do not take an extra tablet to make up for the dose you forgot. Wait and take your next tablet at the regular time. This is very important. Too much Wellbutrin can increase your chance of having a seizure.
  • If you take too much Wellbutrin, or overdose, call your local emergency room or poison control center right away.
  • Do not take any other medicines while using Wellbutrin unless your doctor has told you it is okay.
  • It may take several weeks for you to feel that Wellbutrin is working. Once you feel better, it is important to keep taking Wellbutrin exactly as directed by your doctor. Call your doctor if you do not feel Wellbutrin is working for you.
  • Do not change your dose or stop taking Wellbutrin without talking with your doctor first.

How Should Zoloft Be Taken?

Take Zoloft exactly as prescribed. Your healthcare provider may need to change the dose of Zoloft until it is the right dose for you.

Zoloft Tablets may be taken with or without food.

Zoloft Oral Solution may look cloudy or hazy after mixing, this is normal.

Zoloft Oral Solution must be diluted before use:

Do not mix Zoloft until you are ready to take it.

When diluting Zoloft Oral Solution, use only water, ginger ale, lemon/lime soda, lemonade, or orange juice.

The oral dropper contains latex. If you are sensitive or allergic to latex, ask your healthcare provider or pharmacist about the best way to measure your medicine.

If you miss a dose of Zoloft, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time.Do not take two doses of Zoloft at the same

time.

If you take too much Zoloft, call your healthcare provider or poison control center right away, or go to the nearest hospital emergency room right away.

QUESTION

Depression is a(n) __________ . See Answer
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References

FDA. Wellbutrin Drug Information.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/018644s041MedGuide.pdf
Pfizer. Zoloft Drug Information.
https://www.zoloft.com/

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