What Is a Chromoendoscopy?

Reviewed on 7/1/2020

What does a chromoendoscopy mean?

This Chromoendoscopy helps visualize the inner surface of the bowel (epithelia) during endoscopy.

A chromoendoscopy is a diagnostic procedure in which a chemical substance (called a stain or pigment) is sprayed inside the gut to highlight specific areas or distinguish among the different types of cell layers. This helps visualize the inner surface of the bowel (epithelia) during endoscopy. Chromoendoscopy is a simple, cost-effective, quick, and safe diagnostic method that improves the recognition of the tiny changes in the surface pattern. It does this by enhancing the contrast of raised and deepened areas. 

Three types of stains can be used for chromoendoscopy:

  • Absorptive or vital stains: These stains diffuse or are selectively absorbed across specific epithelia (e.g., Lugol's solution and methylene blue).
  • Contrast stains: These stains highlight surface irregularities (topography) of the inside of the gut by filling the mucosal crevices (e.g., methylene blue).
  • Reactive stains: As the name suggests, these stains undergo chemical reactions with specific cell components, resulting in a color change (e.g., congo red and phenol red).

Why is a chromoendoscopy performed?

A chromoendoscopy may be done to diagnose:

A chromoendoscopy may be used for treatment approaches like:

A chromoendoscopy is avoided if there is a history of an allergy to the dye or stain used for the procedure.


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Why is a chromoendoscopy performed in an ulcerative colitis?

An ulcerative colitis is a type of inflammatory bowel disease (IBD), a condition in which there is long-term inflammation of the large intestine (colon) with peculiar sores or ulcers in the inner lining of the colon. The condition may involve severe diarrhea, pain in the abdomen, loss of appetite, fatigue, fever, and weight loss.

An ulcerative colitis increases the risk of cancers of the colon and rectum. A chromoendoscopy helps monitor the signs of progression toward cancer. In this technique, a dye is sprayed via an endoscope inside the gut which helps the doctor see which parts are affected by the ulcerative colitis. It enables the visualization of the inside of the colon and takes targeted biopsies. It also helps the doctor provide early management for the prevention of the development of cancer and if cancer has developed, to treat it at an early stage. Besides better visualization, the procedure has the advantage of being accurate, safe, quick and less expensive for monitoring or surveillance in case of an ulcerative colitis.

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