What Is Berger’s Disease?

Reviewed on 12/18/2020

What is Berger's?

Berger's disease or immunoglobulin A (IgA) nephropathy is a kidney disorder
Berger's disease or immunoglobulin A (IgA) nephropathy is a kidney disorder

Berger's disease or immunoglobulin A (IgA) nephropathy is a kidney disorder that presents with the passing of blood in the urine. This happens due to swelling of the glomeruli (filtering units of the kidney that produce urine). The swelling is usually caused due to a buildup of a substance called IgA in the kidneys. This hampers the filtration process of the kidneys. IgA is a type of antibody (protein) manufactured by the immune system. When the body is unable to filter the urine, it can't excrete body wastes or eliminate excess fluid from the bloodstream. IgA nephropathy leads to kidney failure and other related complications. It may be acute (attacking quickly and suddenly) or chronic. IgA nephropathy often strikes in the teen or early adult years. It affects more men than women.

Causes:

  • Anyone at any age can get IgA nephropathy, although it’s more common in men. Caucasians and Asians also have a higher incidence of IgA nephropathy than other ethnic groups. The predisposing factors for IgA nephropathy are as follows:
  • No one knows why IgA nephropathy happens, but it can happen more than once and for years. Frequency and duration of the condition do not indicate much about the eventual outcome, and 85% of cases result in no long-term kidney damage, with kidney function remaining normal all the while.
  • In some cases, it can develop after a child or young adult has a viral infection of the upper respiratory or gastrointestinal tracts. For some people, a genetic defect may be linked to the development of IgA nephropathy.

Signs and symptoms:

Diagnosing IgA nephropathy: Blood in the urine is the most common symptom of IgA nephropathy. If blood or protein is found in your urine, a series of tests may be ordered by your doctor. These tests can usually determine if the kidneys are injured and how well they are working.

Treatment options: IgA nephropathy cannot be prevented and has no cure. Some people can live with the disease without any complications. However, half of the people who do get IgA nephropathy may progress to end-stage renal disease. Doctors may recommend

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References
Tashakkorinia N, Muco E, Tudor ME. Berger Disease (Thromboangiitis Obliterans). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; January 2020. https://www.ncbi.nlm.nih.gov/books/NBK499998/

Mayoclinic. IgA nephropathy (Berger's disease). https://www.mayoclinic.org/diseases-conditions/iga-nephropathy/symptoms-causes/syc-20352268

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