What Is the Difference Between HIV-1 and HIV-2?

Reviewed on 8/7/2020

What is HIV?

HIV-1 is the most common form of HIV. HIV-2 is less deadly and mostly found in West Africa.
HIV-1 is the most common form of HIV. HIV-2 is less deadly and mostly found in West Africa.

Human immunodeficiency virus (HIV) attacks the cells of the immune system. CD4+ cells help the body to resist any infections. When the number of these cells is reduced, the body is less resistant, which makes it vulnerable to other infections and diseases. HIV spreads mainly via body fluids (blood and semen) from the infected person.

If untreated, HIV can lead to acquired immunodeficiency syndrome (AIDS). Hence, treating HIV with antiretroviral therapy (ART, HIV medicine) is necessary to reduce the viral load and prevent transmission of HIV to the patient’s sexual partners.

What is the difference between HIV-1 and HIV-2?

There are two main types of the human immunodeficiency virus (HIV), HIV-1 and HIV-2. The difference between HIV-1 and HIV-2 are as follows

  • HIV-1 is the most common type of HIV and accounts for 95% of all infections, whereas HIV-2 is relatively uncommon and less infectious.
  • HIV-2 is mainly concentrated in West Africa and the surrounding countries.
  • HIV-2 is less fatal and progresses more slowly than HIV-1.

Currently, only one antibody test can distinguish between antibodies to HIV-1 or HIV-2.

How is HIV transmitted?

Human immunodeficiency virus (HIV) is transmitted by coming into direct contact with certain body fluids of the person infected with HIV. These fluids are as follows

Transmission occurs only when the fluid gets into the bloodstream of an HIV-negative person through open sores or cuts, by direct injection or a mucous membrane.

The most common ways of spreading HIV are as follows

  • Having anal or vaginal sex with an HIV-positive person
  • Sharing needles with a person who has HIV
  • Less common ways are as follows
  • During pregnancy or breastfeeding
  • Having oral sex
  • Receiving blood products that are contaminated with HIV
  • Getting stuck with an HIV-contaminated needle

What are the symptoms of HIV?

Not everyone will have identical symptoms, as it depends on the person and what stage of the disease they are in.

There are three stages of the human immunodeficiency virus (HIV) infection. Each stage has a unique set of symptoms. These include

Stage 1: Acute HIV infection

This stage starts around two to four weeks after getting HIV. The symptoms are similar to those of the flu, which lasts for a week or two. Symptoms include

Stage 2: Chronic HIV infection

In this stage, the virus multiplies at a low level and people may not experience any symptoms at all. Without HIV treatment, the person can remain in this stage for 10 to 15 years. However, the virus remains active during this stage.

Stage 3: Acquired immunodeficiency syndrome (AIDS)

If left untreated, HIV leads to AIDS. AIDS can weaken the immune system causing several opportunistic diseases. Symptoms include

SLIDESHOW

A Timeline of the HIV/AIDS Pandemic See Slideshow

What are the types of HIV tests?

There are three types of human immunodeficiency virus (HIV) tests used to diagnose HIV infections, which are as follows

  • Antibody tests: These check for HIV antibodies in the blood or oral fluid.
  • Antigen/antibody tests: These help to detect both HIV antibodies and antigens in the blood.
  • Nucleic acid tests: These look for HIV in the blood.

What is the treatment for HIV?

The treatment for human immunodeficiency virus (HIV) involves a combination of medications known as antiretroviral therapy (ART). ART cannot cure HIV; however, it can increase the survival rate of patients.

ART halts the multiplication of the virus and reduces the amount of virus in the body to help the patient stay healthier.

Once the treatment has been started, the patient must remain compliant with the dosage for the medicines to be effective. Noncompliance can result in developing resistance to the medicines.

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References
Medscape Medical Reference







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