What Is the Main Cause of Rectal Cancer?

Reviewed on 4/28/2021

The rectum is the terminal part of the large intestine.
The rectum is the terminal part of the large intestine.

The rectum is the terminal part of the large intestine. The function of the rectum is to store feces till they are expelled from the body. Rectal cancer usually develops over years. Doctors do not know precisely what causes it.

Rectal cancer begins when changes (mutations) in the DNA of the rectal cells cause the cells to multiply and grow uncontrollably. The abnormal cells thus formed accumulate to form a harmful (malignant) tumor known as rectal cancer.

Certain factors increase the risk of rectal cancer, which include

What are the signs and symptoms of rectal cancer?

Many types of rectal cancer are often detected during routine rectal examinations. Signs and symptoms develop later. The earlier ones include

As rectal cancer progresses and spreads to other organs, patients may experience

Blood in the stool (or bleeding) and a change in usual bowel habits are usually the main symptoms that point toward the diagnosis of rectal cancer, particularly if the patient is elderly. The patient should schedule an appointment with their doctor to know if rectal cancer is causing these symptoms. Earlier testing improves the outcome of cancer treatments.

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How is rectal cancer diagnosed?

Rectal cancer is most often detected as a hard mass during routine rectal examinations known as digital rectal exam (DRE). During DRE, the doctor inserts fingers into the patient’s rectum to feel it. They take the patient’s complete medical history and perform a physical exam. To check if the mass is cancerous, the doctor will perform procedures such as

  • Proctoscopy: In this test, the doctor inserts a proctoscope (a hollow tube) through the patient’s anus to visualize their rectum. This is usually done at the doctor’s office and does not involve any special preparation before the procedure.
  • Colonoscopy: In this procedure, the doctor inserts a colonoscope (a long, flexible tube) into the patient’s rectum to look for changes such as polyps and any other abnormal growth in the rectum and colon. This is a hospital-based procedure that needs special preparations such as taking a laxative a night before.
  • Biopsy: The doctor will remove a piece of the patient’s rectum during a colonoscopy. They will send the sample of the rectum to the laboratory to check for the presence of the cancerous cells. This test known as a biopsy provides a definitive diagnosis of rectal cancer.

Once rectal cancer has been diagnosed, the doctor performs certain tests to know the extent of cancer and stage it, which include

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References
Rectal cancer. https://emedicine.medscape.com/article/281237-overview

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