Last reviewed on RxList: 12/8/2004
Wigraine Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 5/26/2016

Wigraine (ergotamine and caffeine) is a combination of an ergot alkaloid and a stimulant used to treat or prevent vascular headaches such as migraine headaches and cluster headaches. The brand name Wigraine is discontinued, but generic versions may be available. Common side effects of Wigraine (ergotamine and caffeine) include:

  • nausea
  • vomiting
  • upset stomach
  • restlessness
  • trouble sleeping
  • dizziness
  • chest pain
  • pain in the extremities
  • numbness and tingling in fingers and toes
  • temporary fast or slow heart rate
  • leg weakness
  • diarrhea
  • swelling, and
  • itching

The average adult dose is 2 tablets at the start of a vascular headache (migraine) attack; followed by 1 additional tablet every ½ hour if needed, up to 6 tablets per attack. Total weekly dosage should not exceed 10 tablets. Wigraine may interact with delavirdine, efavirenz, sibutramine, adenosine, beta blockers, cimetidine, dopamine, fluoxetine, fluvoxamine, metronidazole, nefazodone, zileuton, lithium, nicotine, nitrates, other ergot alkaloids, theophylline, vemurafenib, "triptan" migraine drugs, or products containing caffeine (including coffee, tea, diet aids, and other over-the-counter medications). Tell your doctor all medications and supplements you use. Wigraine may harm a fetus and must not be used during pregnancy. Men and women should use two forms of birth control (e.g., condoms, birth control pill) while taking this medication. If you become pregnant or think you may be pregnant, inform your doctor. Consult your doctor to discuss birth control. This drug may pass into breast milk and could have undesirable effects on a nursing infant. Breastfeeding is not recommended while using this drug.

Our Wigraine (ergotamine and caffeine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Wigraine Consumer Information
SIDE EFFECTS: Nausea, vomiting, upset stomach, restlessness, trouble sleeping, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: slow/fast/irregular heartbeat, numbness/tingling in fingers/toes, blue fingers/toes/nails, cold hands/feet, muscle pain/weakness, severe stomach/abdominal pain, lower back pain, decrease in the amount of urine.

Get medical help right away if you have any very serious side effects, including: chest/jaw/left arm pain, confusion, slurred speech, vision changes, weakness on one side of the body.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Wigraine (Ergotamine and Caffeine)


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Wigraine Professional Information


In order of decreasing severity; precordial distress and pain, muscle pains in the extremities, numbness and tingling in fingers and toes, transient tachycardia or bradycardia, vomiting, nausea, weakness in the legs, diarrhea, localized edema and itching.


Read the entire FDA prescribing information for Wigraine (Ergotamine and Caffeine)

© Wigraine Patient Information is supplied by Cerner Multum, Inc. and Wigraine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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