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Xalatan

Last reviewed on RxList: 10/29/2018
Xalatan Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 10/29/2018

Xalatan (latanoprost) is a prostaglandin analogue ophthalmic solution used to treat pressure in the eye (glaucoma, ocular hypertension) by decreasing liquid in the eye. Xalantan is available as a generic drug. Side effects of Xalatan include:

  • blurred vision,
  • burning/stinging/itching/redness of the eye after using the drops,
  • feeling as if something is in the eye,
  • changes in eyelash number/color/length/thickness,
  • eyelid skin darkening,
  • browning of the iris,
  • watery eyes,
  • dry eyes,
  • eye discomfort,
  • lid crusting/discomfort,
  • increased sensitivity to light,
  • cold or flu-like symptoms (stuffy nose, sneezing, sore throat),
  • headache,
  • dizziness, or
  • muscle/joint pain.

Serious side effects include:

  • oozing or eye discharge,
  • chest pain,
  • vision changes,
  • light sensitivity, and
  • redness, swelling, itching or pain in the eye.

Xalatan (latanoprost) is available in an ophthalmic solution; strength is 0.005% (50 μg/mL). It is administered by an eyedropper. The amount is determined by the doctor. Xalatan may interact with other drugs. Tell your doctor all medications and supplements you use. Benefits versus risks should be considered in pregnant women; it is not known if the drug is present in breast milk. Consult your doctor before breastfeeding. Use in pediatrics is not discussed; any use of this drug should be first discussed with a doctor, preferably an ophthalmologist.

Our Xalantan Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Xalatan Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using latanoprost and call your doctor at once if you have:

  • eye swelling, redness, severe discomfort, crusting or drainage (may be signs of infection);
  • red, swollen, or itchy eyelids;
  • increased sensitivity to light;
  • vision changes; or
  • severe burning, stinging, or irritation after using this medicine.

Common side effects may include:

  • puffy eyelids;
  • stinging, burning, or redness of the eyes;
  • blurred vision;
  • feeling like something is in your eye;
  • dry or watery eyes; or
  • cold or flu symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Xalatan (Latanoprost Ophthalmic)

Xalatan Professional Information

SIDE EFFECTS

The following adverse reactions were reported in postmarketing experience and are discussed in greater detail in other sections of the label:

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, the adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

XALATAN was studied in three multicenter, randomized, controlled clinical trials. Patients received 50 mcg/mL XALATAN once daily or 5 mg/mL active-comparator (timolol) twice daily. The patient population studied had a mean age of 65±10 years. Seven percent of patients withdrew before the 6-month endpoint.

Table 1: Ocular Adverse Reactions and Ocular Signs/Symptoms Reported by 5-15% of Patients Receiving Latanoprost

Symptom/Finding Adverse Reactions (incidence (%))
Latanoprost
(n=460)
Timolol
(n=369)
Foreign body sensation 13 8
Punctate keratitis 10 9
Stinging 9 12
Conjunctival hyperemia 8 3
Blurred vision 8 8
Itching 8 8
Burning 7 8
Increased pigmentation of the Iris 7 0

Less than 1% of the patients treated with XALATAN required discontinuation of therapy because of intolerance to conjunctival hyperemia.

Table 2: Adverse Reactions That Were Reported in 1-5% of Patients Receiving Latanoprost

  Adverse Reactions (incidence (%))
Latanoprost
(n=460)
Timolol
(n=369)
Ocular Events/Signs and Symptoms
  Excessive tearing 4 6
  Eyelid discomfort/pain 4 2
  Dry eye 3 3
  Eye pain 3 3
  Eyelid margin crusting 3 3
  Erythema of the eyelid 3 2
  Photophobia 2 1
  Eyelid edema 1 3
 Systemic Events
  Upper respiratory tract infection/nasopharyngitis/influenza 3 3
  Myalgia/arthralgia/back pain 1 0.5
  Rash/allergic skin reaction 1 0.3

The ocular event/signs and symptoms of blepharitis have been identified as “commonly observed” through analysis of clinical trial data.

Postmarketing Experience

The following reactions have been identified during postmarketing use of XALATAN in clinical practice. Because they are reported voluntarily from a population of unknown size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The reactions, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to XALATAN, or a combination of these factors, include:

Nervous System disorders: Dizziness; headache; toxic epidermal necrolysis

Eye Disorders: Eyelash and vellus hair changes of the eyelid (increased length, thickness, pigmentation, and number of eyelashes); keratitis; corneal edema and erosions; intraocular inflammation (iritis/uveitis); macular edema, including cystoid macular edema; trichiasis; periorbital and lid changes resulting in deepening of the eyelid sulcus; iris cyst; eyelid skin darkening; localised skin reaction on the eyelids; conjunctivitis; pseudopemphigoid of the ocular conjunctiva

Respiratory, Thoracic and Mediastinal Disorders: Asthma and exacerbation of asthma; dyspnea

Skin and Subcutaneous Tissue Disorders: Pruritus

Infections and Infestations: Herpes keratitis

Cardiac Disorders: Angina; palpitations; angina unstable

General Disorders and Administration Site Conditions: Chest pain

Read the entire FDA prescribing information for Xalatan (Latanoprost Ophthalmic)

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Read the Xalatan User Reviews »

© Xalatan Patient Information is supplied by Cerner Multum, Inc. and Xalatan Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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