Xcopri vs. Depakote

Are Xcopri and Depakote the Same Thing?

Xcopri (cenobamate tablets) and Depakote (divalproex sodium) are antiepileptic drugs (AED) used to treat epilepsy.

Xcopri is used to treat partial-onset seizures in adult patients.

Depakote is also used to treat manic episodes associated with bipolar disorder, and migraine headaches.

Side effects of Xcopri and Depakote that are similar include drowsiness and double vision/vision changes.

Side effects of Xcopri that are different from Depakote include dizziness, fatigue, and headache.

Side effects of Depakote that are different from Xcopri include weakness, nausea, vomiting, stomach upset, diarrhea, constipation, mood swings, changes in menstrual periods, enlarged breasts, weight changes, agitation, tremor (shaking), unusual or unpleasant taste in your mouth, and hair loss.

Both Xcopri and Depakote may interact with other antiepileptic drugs (AEDs).

Xcopri may also interact with CYP2B6 and CYP3A substrates, CYP2C19 substrates, oral contraceptives, other drugs that shorten the QT interval, alcohol, and other CNS depressants.

Depakote may also interact with ritonavir, phenobarbital, primidone, aspirin, carbapenem antibiotics, felbamate, rifampin, amitriptyline, nortriptyline, carbamazepine, clonazepam, diazepam, ethosuximide, lamotrigine, tolbutamide, warfarin, zidovudine, lorazepam, and topiramate.

What Are Possible Side Effects of Xcopri?

Common side effects of Xcopri include:

    • drowsiness,
    • dizziness,
    • fatigue,
    • double vision, and
    • headache

    What Are Possible Side Effects of Depakote?

    Common side effects of Depakote include:

    • drowsiness,
    • weakness,
    • nausea,
    • vomiting,
    • stomach upset,
    • diarrhea,
    • constipation,
    • mood swings,
    • changes in menstrual periods,
    • enlarged breasts,
    • weight changes,
    • agitation,
    • tremor (shaking),
    • vision changes,
    • unusual or unpleasant taste in your mouth, and
    • hair loss.

    Antiepileptic drugs (AEDs), including Depakote, increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication. Tell your doctor if you have new or worsening depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior.

    What Is Xcopri?

    Xcopri (cenobamate tablets) is an antiepileptic drug (AED) used to treat partial-onset seizures in adult patients.

    What Is Depakote?

    Depakote (divalproex sodium) is a stable coordination compound comprised of sodium valproate and valproic acid used to treat manic episodes associated with bipolar disorder, epilepsy, and migraine headaches. Generic Depakote (termed divalproex sodium) is available under several other names.

SLIDESHOW

What Is Epilepsy? Symptoms, Causes, and Treatments See Slideshow

What Drugs Interact With Xcopri?

Xcopri may interact with other medicines such as:

  • antiepileptic drugs (AEDs),
  • CYP2B6 and CYP3A substrates,
  • CYP2C19 substrates,
  • oral contraceptives,
  • other drugs that shorten the QT interval,
  • alcohol, and
  • other CNS depressants

Tell your doctor all medications and supplements you use and all vaccines you recently received.

What Drugs Interact With Depakote?

Depakote may interact with other medicines such as:

  • ritonavir,
  • phenytoin,
  • carbamazepine,
  • phenobarbital,
  • primidone,
  • aspirin,
  • carbapenem antibiotics,
  • felbamate,
  • rifampin,
  • amitriptyline,
  • nortriptyline,
  • carbamazepine,
  • clonazepam,
  • diazepam,
  • ethosuximide,
  • lamotrigine,
  • tolbutamide,
  • warfarin,
  • zidovudine,
  • lorazepam, and
  • topiramate

Tell your doctor all medications and supplements you use.

How Should Xcopri Be Taken?

The recommended initial dosage of Xcopri is 12.5 mg once daily, adjusted to the recommended maintenance dosage of 200 mg once daily.

How Should Depakote Be Taken?

The recommended initial dose of Depakote to treat mania is 750 mg daily in divided doses. The dose of Depakote to treat epilepsy as monotherapy should be initiated at 10 to 15 mg/kg/day. The recommended starting dose of Depakote to treat migraines is 250 mg twice daily.

QUESTION

If you have had a seizure, it means you have epilepsy. See Answer
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References
SK Biopharmaceuticals Co., Ltd. Xcopri.

www.xcopri.com

AbbVie. Depakote Product Information.

https://www.depakote.com/

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