Xeljanz vs. Otezla

Reviewed on 9/22/2020

Are Xeljanz and Otezla the Same Thing?

Xeljanz (tofacitinib citrate) and Otezla (apremilast) are used to treat different types of arthritis.

Xeljanz is used to treat adults with moderate to severely active rheumatoid arthritis (RA) who have not responded well to methotrexate, or cannot tolerate it.

Otezla is used to treat adult patients with active psoriatic arthritis.

Xeljanz and Otezla belong to different drug classes. Xeljanz is a Janus kinase (JAK) inhibitor and Otezla is a phosphodiesterase 4 (PDE4) inhibitor.

Side effects of Xeljanz and Otezla that are similar include upper respiratory tract infections, headache, diarrhea, and runny or stuffy nose.

Side effects of Xeljanz that are different from Otezla include and cold symptoms such as sore throat.

Side effects of Otezla that are different from Xeljanz include nausea, vomiting, abdominal pain, fatigue, indigestion/heartburn, decreased appetite, insomnia, back pain, frequent bowel movements, depression, bronchitis, tooth abscess, and sinus headache.

Xeljanz may interact with aprepitant, bosentan, conivaptan, haloperidol, imatinib, isoniazid, St. John's wort, ticlopidine, antibiotics, antidepressants, antifungals, hepatitis C medications boceprevir or telaprevir, heart or blood pressure medicines, HIV or AIDS medicines, medications to treat excess stomach acid, medicines to prevent organ transplant rejection, nonsteroidal anti-inflammatory drugs (NSAIDs), other arthritis medications, seizure medications, and steroids.

Otezla may interact with CYP450 inducers (such as rifampin).

What Are Possible Side Effects of Xeljanz?

Side effects of Xeljanz include:

Common side effects of Xeljanz include:

  • upper respiratory tract infections,
  • headache,
  • diarrhea, and
  • cold symptoms such as sore throat, runny or stuffy nose.

Tell your doctor if you experience serious side effects of Xeljanz including:

What Are Possible Side Effects of Otezla?

Common side effects of Otezla include:

  • diarrhea,
  • headache,
  • nausea,
  • upper respiratory tract infection,
  • vomiting,
  • runny or stuffy nose,
  • abdominal pain,
  • fatigue,
  • indigestion/heartburn,
  • decreased appetite,
  • insomnia,
  • back pain,
  • frequent bowel movements,
  • depression,
  • bronchitis,
  • tooth abscess, and
  • sinus headache.

QUESTION

The term arthritis refers to stiffness in the joints. See Answer

What Is Xeljanz?

Xeljanz (tofacitinib citrate) is a Janus kinase (JAK) inhibitor used to treat adults with moderate to severely active rheumatoid arthritis (RA) who have not responded well to methotrexate, or cannot tolerate it.

What Is Otezla?

Otezla (apremilast) is a phosphodiesterase 4 (PDE4) inhibitor used to treat adult patients with active psoriatic arthritis.

What Drugs Interact With Xeljanz?

Xeljanz may interact with aprepitant, bosentan, conivaptan, haloperidol, imatinib, isoniazid, St. John's wort, ticlopidine, antibiotics, antidepressants, antifungals, hepatitis C medications boceprevir or telaprevir, heart or blood pressure medicines, HIV or AIDS medicines, medications to treat excess stomach acid, medicines to prevent organ transplant rejection, nonsteroidal anti-inflammatory drugs (NSAIDs), other arthritis medications, seizure medications, or steroids. Tell your doctor all medications and supplements you use.

What Drugs Interact With Otezla?

Otezla may interact with CYP450 inducers (such as rifampin).

How Should Xeljanz be Taken?

The recommended dose of Xeljanz is 5 mg twice daily.

How Should Otezla be Taken?

The recommended maintenance dosage is 30 mg twice daily taken orally starting on Day 6, after 5 days of an initial schedule of titration dosing.

SLIDESHOW

What Is Rheumatoid Arthritis (RA)? Symptoms, Treatment, Diagnosis See Slideshow
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
Pfizer. Xeljanz Product Monograph.

https://www.xeljanz.com

Celgene Corporation. Otezla Prescribing Information.

https://www.otezla.com

Health Solutions From Our Sponsors