Xelpros Side Effects Center

Last updated on RxList: 1/4/2021
Xelpros Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Xelpros?

Xelpros (latanoprost ophthalmic emulsion) is a prostaglandin F2a analog indicated for reduction of elevated intraocular pressure in patients with open-angle glaucoma, or ocular hypertension.

What Are Side Effects of Xelpros?

Common side effects of Xelpros include:

  • eye pain/stinging,
  • ocular hyperemia,
  • eye redness,
  • eye discharge,
  • growth of eyelashes,
  • eyelash thickening,
  • itchy eyes,
  • dry eye,
  • vision problems,
  • eyelid redness or swelling, or
  • feeling as if something is in the eye

Dosage for Xelpros

The dose of Xelpros is one drop in the affected eye(s) once daily in the evening.

What Drugs, Substances, or Supplements Interact with Xelpros?

Xelpros may interact with other prostaglandins or drugs containing thimerosal used at the same time. Tell your doctor all medications and supplements you use.

Xelpros During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Xelpros; it is unknown how it would affect a fetus. It is unknown if Xelpros passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Xelpros (latanoprost ophthalmic emulsion) 0.005%, for Topical Ophthalmic Use Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Xelpros Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using latanoprost and call your doctor at once if you have:

  • eye swelling, redness, severe discomfort, crusting or drainage (may be signs of infection);
  • red, swollen, or itchy eyelids;
  • increased sensitivity to light;
  • vision changes; or
  • severe burning, stinging, or irritation after using this medicine.

Common side effects may include:

  • watery eyes;
  • itchy eyes;
  • puffy eyelids;
  • stinging, burning, or redness of the eyes;
  • blurred vision;
  • feeling like something is in your eye;
  • your eyes may be more sensitive to light;
  • darkened eye color; or
  • eyelash thickening.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Xelpros (Latanoprost Ophthalmic Emulsion)


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Xelpros Professional Information


The following adverse reactions were reported in postmarketing experience and are discussed in greater detail in other sections of the label:

  • Iris pigmentation changes [see WARNINGS AND PRECAUTIONS]
  • Eyelid skin darkening [see WARNINGS AND PRECAUTIONS]
  • Eyelash changes (increased length, thickness, pigmentation, and number of lashes) [see WARNINGS AND PRECAUTIONS]
  • Intraocular inflammation (iritis/uveitis) [see WARNINGS AND PRECAUTIONS]
  • Macular edema, including cystoid macular edema [see WARNINGS AND PRECAUTIONS]

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in clinical practice.

Across multiple clinical trials conducted with XELPROS (latanoprost ophthalmic emulsion) 0.005%, the most frequently reported ocular adverse reactions were eye pain/stinging upon instillation and ocular hyperemia, reported in 55% and 41% of XELPROS treated patients, respectively (Table 1). Less than 1% of patients discontinued therapy because of intolerance to the eye pain/stinging or to the ocular hyperemia.

Table 1. Ocular Adverse Reactions Reported by ≥ 1% of Subjects Receiving XELPROS

System Organ Class/
   Preferred Term
(N = 448)
Eye disorders325 (73%)
  Eye pain / stinging246 (55%)
  Ocular hyperemia185 (41%)
  Conjunctival hyperemia65 (15%)
  Eye discharge53 (12%)
  Growth of eyelashes47 (11%)
  Eyelash thickening35 (8%)
  Ocular Itching20 (5%)
  Visual acuity reduced16 (4%)
  Dry eye13 (3%)
  Erythema of eyelid14 (3%)
  Foreign body sensation in eyes9 (2%)
  Punctate keratitis6 (1%)
  Eyelash discoloration5 (1%)
  Eyelid edema7 (2%)
  Conjunctival edema5 (1%)

Postmarketing Experience

The following reactions have been identified during postmarketing use of topical latanoprost products in clinical practice. Because they are reported voluntarily from a population of unknown size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

The reactions, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to latanoprost ophthalmic emulsion or a combination of these factors, include:

  • Nervous System Disorders: Dizziness, headache, toxic epidermal necrolysis
  • Eye Disorders: Corneal edema and erosions; intraocular inflammation (iritis/uveitis); macular edema, including cystoid macular edema; trichiasis; periorbital and lid changes resulting in deepening of the eyelid sulcus; iris cyst; eyelid skin darkening; localized skin reaction on the eyelids; conjunctivitis; pseudopemphigoid of the ocular conjunctiva
  • Respiratory, Thoracic and Mediastinal Disorders: Asthma and exacerbation of asthma; dyspnea
  • Skin and Subcutaneous Tissue Disorders: Pruritus
  • Infections and Infestations: Herpes keratitis
  • Cardiac Disorders: Angina; palpitations; angina unstable
  • General Disorders and Administration Site Conditions: Chest pain

Read the entire FDA prescribing information for Xelpros (Latanoprost Ophthalmic Emulsion)

© Xelpros Patient Information is supplied by Cerner Multum, Inc. and Xelpros Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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