Xenleta vs. Avelox

Xenleta (lefamulin) and Avelox (moxifloxacin) are antibiotics used to treat bacterial pneumonia.

Avelox is also used to treat bacterial infections such as bronchitis, and others that may infect the sinuses, skin, or abdomen.

Xenleta and Avelox are different types of antibiotics. Xenleta is a pleuromutilin antibacterial and Avelox is a fluoroquinolone antibiotic.

Side effects of Xenleta and Avelox that are similar include nausea, headache, diarrhea, and vomiting.

Side effects of Xenleta that are different from Avelox include injection site reactions, elevated liver enzymes, low blood potassium, and insomnia.

Side effects of Avelox that are different from Xenleta include abdominal discomfort, mouth sores, dizziness, blurred vision, nervousness, anxiety, agitation, skin itching, vaginal discomfort (itch or burning sensation), and connective tissue problems (tendon rupture and joint problems).

Both Xenleta and Avelox may interact with antidepressants and heart rhythm medications.

Xenleta may also interact with strong CYP3A4 inducers or P-gp inducers, strong CYP3A inhibitors or P-gp inhibitors, alprazolam, diltiazem, verapamil, simvastatin, vardenafil, antipsychotics, erythromycin, and moxifloxacin.

Avelox may also interact with antacids that contain magnesium or aluminum, sucralfate, didanosine; vitamin or mineral supplements that contain aluminum, iron, magnesium, or zinc; theophylline, blood thinners, diuretics (water pills), insulin or oral diabetes medicines, medicines to treat mental illness, steroids, and nonsteroidal anti-inflammatory drugs (NSAIDs).

Common side effects of Xenleta include:

• injection site reactions,
• elevated liver enzymes,
• nausea,
• low blood potassium,
• insomnia,
• headache,
• diarrhea,
• nausea, and
• vomiting

Common side effects of Avelox include:

• abdominal discomfort
• diarrhea
• nausea
• vomiting
• mouth sores
• headache
• dizziness
• blurred vision
• nervousness
• anxiety
• agitation
• skin itching, and
• vaginal discomfort (itch or burning sensation)

Xenleta (lefamulin) is a pleuromutilin antibacterial indicated for the treatment of adults with community-acquired bacterial pneumonia (CABP) caused by susceptible microorganisms.

Avelox is a fluoroquinolone antibiotic medicine used to treat certain types of infections caused by certain germs called bacteria in adults 18 years or older. These bacterial infections include:

• Community Acquired Pneumonia
• Uncomplicated Skin and Skin Structure Infections
• Complicated Skin and Skin Structure Infections
• Complicated Intra-Abdominal Infections
• Plague
• Acute Bacterial Sinusitis
• Acute Bacterial Exacerbation of Chronic Bronchitis

Xenleta may interact with strong CYP3A4 inducers or P-gp inducers, strong CYP3A inhibitors or P-gp inhibitors, alprazolam, diltiazem, verapamil, simvastatin, vardenafil, antiarrhythmics, antipsychotics, erythromycin, moxifloxacin, and tricyclic antidepressants. Tell your doctor all medications and supplements you use. Xenleta is not recommended for use during pregnancy; it may harm a fetus. Females of reproductive potential are advised to use effective contraception during treatment with Xenleta and for 2 days after the final dose. It is unknown if Xenleta passes into breast milk. Because of the potential for adverse reactions in nursing infants, breastfeeding is not recommended while using Xenleta. Women should pump and discard breast milk for the duration of treatment with Xenleta and for 2 days after the final dose.

Avelox may interact with blood thinners, antibiotics, antidepressants, anti-malaria medications, medicine to prevent or treat nausea and vomiting, medicines to treat psychiatric disorders, migraine headache medicines, nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, or narcotics.

The recommended dosage of Xenleta is 150 mg every 12 hours by intravenous infusion over 60 minutes for 5 to 7 days or 600 mg orally every 12 hours for 5 days.

• Take Avelox once a day exactly as prescribed by your healthcare provider.
• Take Avelox at about the same time each day.
• Avelox Tablets should be swallowed.
• Avelox can be taken with or without food.
• Drink plenty of fluids while taking Avelox.
• Avelox Injection is given to you by intravenous infusion into your vein slowly, over 60 minutes, as prescribed by your healthcare provider.
• Do not skip any doses, or stop taking Avelox even if you begin to feel better, until you finish your prescribed treatment, unless:
  • You have tendon effects (see “What is the most important information I should know about Avelox?”).
  • You have nerve problems. See “What is the most important information I should know about Avelox?”
  • You have central nervous system problems. See “What is the most important information I should know about Avelox?”
  • You have a serious allergic reaction (see “What are the possible side effects of Avelox?”), or your healthcare provider tells you to stop.
• This will help make sure that all of the bacteria are killed and lower the chance that the bacteria will become resistant to Avelox. If this happens, Avelox and other antibiotic medicines may not work in the future.
• If you miss a dose of Avelox, take it as soon as you remember. Do not take more than 1 dose of Avelox in one day.
• If you take too much, call your healthcare provider or get medical help immediately.