Xenleta vs. Keflex

Are Xenleta and Keflex the Same Thing?

Xenleta (lefamulin) and Keflex (cephalexin) are used to treat different types of bacterial infections.

Xenleta is used to treat adults with community-acquired bacterial pneumonia (CABP) caused by susceptible microorganisms.

Keflex is also used before dental procedures in patients identified with certain heart-related conditions to prevent bacterial infections of the heart known as endocarditis.

Xenleta and Keflex are different types of antibiotics. Xenleta is a pleuromutilin antibacterial and Keflex is a cephalosporin antibiotic.

Side effects of Xenleta and Keflex that are similar include headache, diarrhea, nausea, and vomiting.

Side effects of Xenleta that are different from Keflex include injection site reactions, elevated liver enzymes, low blood potassium, and insomnia.

Side effects of Keflex that are different from Xenleta include dizziness, tiredness, stomach upset, abdominal pain, joint pain, vaginal itching or discharge, itching, swelling, and rash.

Xenleta may interact with strong CYP3A4 inducers or P-gp inducers, strong CYP3A inhibitors or P-gp inhibitors, alprazolam, diltiazem, verapamil, simvastatin, vardenafil, antiarrhythmics, antipsychotics, erythromycin, moxifloxacin, and tricyclic antidepressants.

Keflex may interact with blood thinners, metformin, or probenecid.

What Are Possible Side Effects of Xenleta?

Common side effects of Xenleta include:

  • injection site reactions,
  • elevated liver enzymes,
  • nausea,
  • low blood potassium,
  • insomnia,
  • headache,
  • diarrhea,
  • nausea, and
  • vomiting

What Are Possible Side Effects of Keflex?

Common side effects of Keflex include:

  • diarrhea,
  • dizziness,
  • tiredness,
  • headache,
  • stomach upset,
  • abdominal pain,
  • joint pain,
  • vaginal itching or discharge,
  • nausea,
  • vomiting,
  • itching,
  • swelling, and
  • rash.

What Is Xenleta?

Xenleta (lefamulin) is a pleuromutilin antibacterial indicated for the treatment of adults with community-acquired bacterial pneumonia (CABP) caused by susceptible microorganisms.

What Is Keflex?

Keflex (cephalexin) is a cephalosporin antibiotic prescribed to treat bacterial infections. Keflex is also used before dental procedures in patients identified with certain heart-related conditions to prevent bacterial infections of the heart known as endocarditis. Keflex is available as a generic drug.

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What Drugs Interact With Xenleta?

Xenleta may interact with strong CYP3A4 inducers or P-gp inducers, strong CYP3A inhibitors or P-gp inhibitors, alprazolam, diltiazem, verapamil, simvastatin, vardenafil, antiarrhythmics, antipsychotics, erythromycin, moxifloxacin, and tricyclic antidepressants. Tell your doctor all medications and supplements you use. Xenleta is not recommended for use during pregnancy; it may harm a fetus. Females of reproductive potential are advised to use effective contraception during treatment with Xenleta and for 2 days after the final dose. It is unknown if Xenleta passes into breast milk. Because of the potential for adverse reactions in nursing infants, breastfeeding is not recommended while using Xenleta. Women should pump and discard breast milk for the duration of treatment with Xenleta and for 2 days after the final dose.

What Drugs Interact With Keflex?

Keflex and amoxicillin may interact with probenecid and blood thinners.

Keflex may also interact with metformin.

How Should Xenleta Be Taken?

The recommended dosage of Xenleta is 150 mg every 12 hours by intravenous infusion over 60 minutes for 5 to 7 days or 600 mg orally every 12 hours for 5 days.

How Should Keflex Be Taken?

Keflex dosage depends on the condition being treated. Keflex should be used with caution in patients who have kidney disease and those who report a history of penicillin allergy.

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References
SOURCE:

Nabriva Therapeutics. Xenleta Product Information.

https://www.xenleta.com

FDA. Keflex Product Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/050405s097lbl.pdf

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