Slideshows Images Quizzes

Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. See additional information.

Xenleta vs. Zosyn

Reviewed on 9/4/2019

Are Xenleta and Zosyn the Same Thing?

Xenleta (lefamulin) and Zosyn (piperacillin and tazobactam for injection) are used to treat pneumonia.

Zosyn is also used to treat many different infections caused by bacteria, such as urinary tract infections (UTIs), bone and joint infections, severe vaginal infections, stomach infections, and skin infections.

Xenleta and Zosyn are different types of antibiotics. Xenleta is a pleuromutilin and Zosyn is a combination of a penicillin antibiotic and a beta-lactamase inhibitor.

Side effects of Xenleta and Zosyn that are similar include injection site reactions, trouble sleeping (insomnia), headache, diarrhea, nausea, and vomiting.

Side effects of Xenleta that are different from Zosyn include elevated liver enzymes and low blood potassium.

Side effects of Zosyn that are different from Xenleta include dizziness, agitation, stomach pain or upset, constipation, runny nose, anxiety, skin rash or itching, and vaginal discharge or itching.

Xenleta may interact with strong CYP3A4 inducers or P-gp inducers, strong CYP3A inhibitors or P-gp inhibitors, alprazolam, diltiazem, verapamil, simvastatin, vardenafil, antiarrhythmics, antipsychotics, erythromycin, moxifloxacin, and tricyclic antidepressants.

Zosyn may interact with probenecid, antibiotics, blood thinners, or medications used to prevent blood clots.

What Are Possible Side Effects of Xenleta?

Common side effects of Xenleta include:

  • injection site reactions,
  • elevated liver enzymes,
  • nausea,
  • low blood potassium,
  • insomnia,
  • headache,
  • diarrhea,
  • nausea, and
  • vomiting

What Are Possible Side Effects of Zosyn?

Common side effects of Zosyn include:

  • swelling,
  • redness,
  • pain,
  • soreness or
  • irritation;
  • dizziness,
  • agitation,
  • trouble sleeping (insomnia),
  • nausea,
  • vomiting,
  • stomach pain or upset,
  • diarrhea,
  • constipation,
  • headache,
  • runny nose,
  • anxiety,
  • skin rash or
  • itching, or
  • vaginal discharge or itching.

Tell your doctor if you have serious side effects of Zosyn including muscle cramps or spasms, swelling of the arms/legs/hands/feet, easy bruising or bleeding, chest pain, confusion, new signs of infection (such as fever, persistent sore throat), severe abdominal or stomach pain, slow/fast/irregular heartbeat, persistent nausea or vomiting, seizures, extreme tiredness, dark or cloudy urine, change in the amount of urine, yellowing eyes or skin, or serious skin reactions (rash, peeling, sores, or blisters).

What Is Xenleta?

Xenleta (lefamulin) is a pleuromutilin antibacterial indicated for the treatment of adults with community-acquired bacterial pneumonia (CABP) caused by susceptible microorganisms.

What Is Zosyn?

Zosyn (piperacillin and tazobactam for injection) is a combination of two antibiotics used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, skin infections, and pneumonia. Zosyn is available in generic form.

SLIDESHOW

Fungal Skin Infections: Types, Symptoms, and Treatments See Slideshow

What Drugs Interact With Xenleta?

Xenleta may interact with strong CYP3A4 inducers or P-gp inducers, strong CYP3A inhibitors or P-gp inhibitors, alprazolam, diltiazem, verapamil, simvastatin, vardenafil, antiarrhythmics, antipsychotics, erythromycin, moxifloxacin, and tricyclic antidepressants. Tell your doctor all medications and supplements you use. Xenleta is not recommended for use during pregnancy; it may harm a fetus. Females of reproductive potential are advised to use effective contraception during treatment with Xenleta and for 2 days after the final dose. It is unknown if Xenleta passes into breast milk. Because of the potential for adverse reactions in nursing infants, breastfeeding is not recommended while using Xenleta. Women should pump and discard breast milk for the duration of treatment with Xenleta and for 2 days after the final dose.

What Drugs Interact With Zosyn?

Zosyn may interact with probenecid, antibiotics, blood thinners, or any other medication used to prevent blood clots. Tell your doctor all medications you use.

How Should Xenleta Be Taken?

The recommended dosage of Xenleta is 150 mg every 12 hours by intravenous infusion over 60 minutes for 5 to 7 days or 600 mg orally every 12 hours for 5 days.

How Should Zosyn Be Taken?

The usual total daily dose of Zosyn for adults is 3.375 g every six hours totaling 13.5 g (12.0 g piperacillin/1.5 g tazobactam).

QUESTION

Bowel regularity means a bowel movement every day. See Answer
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
SOURCE:

Nabriva Therapeutics. Xenleta Product Information.

https://www.xenleta.com

Pfizer. Zosyn Product Information.

http://labeling.pfizer.com/showlabeling.aspx?id=416
CONTINUE SCROLLING FOR RELATED SLIDESHOW

Health Solutions From Our Sponsors