Slideshows Images Quizzes

Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. See additional information.

Xifaxan vs. Rifampin

Reviewed on 8/13/2019

Are Xifaxan and Rifampin the Same Thing?

Xifaxan (rifaximin) and rifampin are antibiotics used to treat diarrhea.

Xifaxan is used to treat patients 12 years of age and older with travelers' diarrhea caused by noninvasive strains of Escherichia coli (E. coli), and to lower the risk of worsened brain function, or hepatic encephalopathy, in adults with liver failure.

Rifampin is also used to treat or prevent tuberculosis (TB). Rifampin may also be used to eliminate a type of bacteria from your nose and throat that may cause meningitis or other infections.

A brand name for rifampin is Rifadin.

Side effects of Xifaxan and rifampin that are similar include nausea, vomiting, gas, headache, dizziness, and tired feeling.

Side effects of Xifaxan that are different from rifampin include constipation, bloating, stomach pain, feeling like you need to urgently empty your bowel, feeling your bowel is not completely empty, and swelling in your hands, feet, or torso.

Side effects of rifampin that are different from Xifaxan include heartburn, upset stomach, loss of appetite, diarrhea, stomach cramps, drowsiness, muscle weakness, pain in your arms or legs, vision problems, flushing (warmth, redness, or tingly feeling), confusion, changes in behavior, and trouble concentrating.

Both Xifaxan and rifampin may interact with antiviral medicines, antibiotics, antifungal medicines, blood thinners, medicines to prevent organ transplant rejection, and heart or blood pressure medicines.

Rifampin may also interact with alcohol, sulfasalazine, theophylline, birth control pills or hormone replacement therapy, thyroid medicines, drugs that lower cholesterol, drugs to treat depression or mental illness, medicines to treat or prevent malaria, narcotics, oral diabetes medications, sedatives, seizure medicines, and steroids.

What Are Possible Side Effects of Xifaxan?

Side effects of Xifaxan include:

  • nausea,
  • vomiting,
  • constipation,
  • bloating,
  • gas,
  • stomach pain,
  • feeling like you need to urgently empty your bowel,
  • feeling your bowel is not completely empty,
  • headache,
  • dizziness,
  • tired feeling, or
  • swelling in your hands, feet, or torso.

Tell your doctor if you develop serious side effects of Xifaxan including:

What Are Possible Side Effects of Rifampin?

Common side effects of Rifampin include:

  • upset stomach,
  • heartburn,
  • nausea,
  • menstrual changes,
  • headache,
  • drowsiness,
  • tired feeling, or
  • dizziness.

Rifadin may also produce a harmless, red or orange coloration of urine, stools, sweat, saliva, or tears. Soft contact lenses may be permanently stained. Tell your doctor if you have unlikely but serious side effects of Rifadin including:

  • flu-like symptoms (fever, chills, headache, muscle aches),
  • changes in amount of urine,
  • persistent nausea or vomiting,
  • stomach or abdominal pain,
  • dark urine,
  • yellowing eyes or skin,
  • mental/mood changes (e.g., confusion, unusual behavior),
  • unusual tiredness,
  • easy bruising or bleeding,
  • small red spots on the skin, or
  • joint pain and swelling.

What Is Xifaxan?

Xifaxan (rifaximin) is an antibiotic indicated for the treatment of patients 12 years of age and older with travelers' diarrhea caused by noninvasive strains of Escherichia coli (E. coli), and to lower the risk of worsened brain function, or hepatic encephalopathy, in adults with liver failure.

What Is Rifampin?

Rifampin is an antibiotic used to treat or prevent tuberculosis (TB). Rifadin may also be used to eliminate a type of bacteria from your nose and throat that may cause meningitis or other infections, even if you do not have an infection.

SLIDESHOW

Fungal Skin Infections: Types, Symptoms, and Treatments See Slideshow

What Drugs Interact With Xifaxan?

Xifaxan may interact with other drugs. Tell your doctor all medications and supplements you use.

What Drugs Interact With Rifampin?

Rifampin may interact with acetaminophen, blood thinners, barbiturates, diazepam or similar medicines, beta-blockers, clofibrate, steroids, birth control pills or estrogen hormone replacement, heart medicines, HIV medicines, ketoconazole, itraconazole, fluconazole, methadone, phenytoin, ethotoin, mephenytoin, sulfa drugs, oral diabetes medication, cyclosporine, or theophylline. Rifadin can interact with many drugs. Tell your doctor all medications you use.

How Should Xifaxan Be Taken?

Xifaxan (rifaximin) tablets for oral administration are film-coated and contain 200 or 550 mg of rifaximin. Usual dosage is 200 mg three times a day for three days for diarrhea and 550mg twice a day for 3 days for hepatic encephalopathy.

How Should Rifampin Be Taken?

To treat tuberculosis, the adult dose of rifampin is 10 mg/kg, in a single daily administration, not to exceed 600 mg/day, oral or IV. The pediatric dose 10-20 mg/kg, not to exceed 600 mg/day, oral or IV.

QUESTION

Bowel regularity means a bowel movement every day. See Answer
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References

Salix Pharmaceuticals. Xifaxan Drug Information.
https://www.xifaxan.com
Sanofi. Rifadin (rifampin) Product Information.
http://products.sanofi.us/rifadin/Rifadin.pdf

Health Solutions From Our Sponsors