Xiidra Side Effects Center

Last updated on RxList: 5/23/2022
Xiidra Side Effects Center

What Is Xiidra?

Xiidra (lifitegrast ophthalmic solution) 5%, for topical ophthalmic use is a lymphocyte function-associated antigen-1 (LFA-1) antagonist indicated for the treatment of the signs and symptoms of dry eye disease (DED).

What Are Side Effects of Xiidra?

Common side effects of Xiidra include:

  • eye irritation or discomfort
  • changes in taste, and
  • blurred vision

Dosage for Xiidra

The dose of Xiidra is one drop twice daily in each eye (approximately 12 hours apart).

What Drugs, Substances, or Supplements Interact with Xiidra?

Contact lenses should be removed prior to administration of Xiidra and can be reinserted 15 minutes after administration. Xiidra may interact with other drugs. Tell your doctor all medications and supplements you use.

Xiidra During Pregnancy and Breastfeeding

During pregnancy, Xiidra should be used only if prescribed; it is unknown if it would affect a fetus. It is unknown if Xiidra passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Xiidra (lifitegrast ophthalmic solution) 5%, for topical ophthalmic use Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

What causes dry eyes? See Answer
Xiidra Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • vision problems; or
  • severe eye redness or irritation.

Common side effects may include:

  • blurred vision;
  • eye irritation; o
  • unusual or unpleasant taste in the mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Xiidra (Lifitegrast Ophthalmic Solution, 5%)

SLIDESHOW

Pink Eye (Conjunctivitis) Symptoms, Causes, Treatments See Slideshow
Xiidra Professional Information

SIDE EFFECTS

The following serious adverse reactions are described elsewhere in the labeling:

  • Hypersensitivity [see CONTRAINDICATIONS]

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

In five clinical trials of DED conducted with lifitegrast ophthalmic solution, 1401 patients received at least one dose of lifitegrast (1287 of which received lifitegrast 5%). The majority of patients (84%) had less than or equal to 3 months of treatment exposure. One hundred-seventy patients were exposed to lifitegrast for approximately 12 months. The majority of the treated patients were female (77%). The most common adverse Sections or subsections omitted from the full prescribing information are not listed. reactions reported in 5%-25% of patients were instillation-site irritation, dysgeusia, and reduced visual acuity.

Other adverse reactions reported in 1%-5% of the patients were blurred vision, conjunctival hyperemia, eye irritation, headache, increased lacrimation, eye discharge, eye discomfort, eye pruritus, and sinusitis.

Postmarketing Experience

The following adverse reactions have been identified during post-approval use of Xiidra. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Rare serious cases of hypersensitivity, including anaphylactic reaction, bronchospasm, respiratory distress, pharyngeal edema, swollen tongue, urticaria, allergic conjunctivitis, dyspnea, angioedema, and allergic dermatitis have been reported. Eye swelling and rash have also been reported [see CONTRAINDICATIONS].

DRUG INTERACTIONS

No Information Provided

Read the entire FDA prescribing information for Xiidra (Lifitegrast Ophthalmic Solution, 5%)

© Xiidra Patient Information is supplied by Cerner Multum, Inc. and Xiidra Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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