Xylocaine DENTAL Injection Side Effects Center

Last updated on RxList: 6/1/2021
Xylocaine DENTAL Injection Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Xylocaine Dental Injection?

Xylocaine DENTAL Solutions (lidocaine HCl 2% and epinephrine 1:50,000 injection) contains an anesthetic and a vasoconstrictor used for the production of local anesthesia for dental procedures by nerve block or infiltration techniques. The brand name Xylocaine DENTAL with epinephrine is discontinued, but generic versions may be available.

What Are Side Effects of Xylocaine Dental Injection?

Common side effects of Xylocaine DENTAL Solutions (lidocaine HCl 2% and epinephrine 1:50,000 injection) include:

Dosage for Xylocaine Dental Injection

The dosage of 2% Xylocaine DENTAL solutions (lidocaine HCl and epinephrine) depends on the physical status of the patient, the area of the oral cavity to be anesthetized, the vascularity of the oral tissues, and the technique of anesthesia used.

What Drugs, Substances, or Supplements Interact with Xylocaine Dental Injection?

Xylocaine DENTAL Solutions may interact with monoamine oxidase inhibitors, tricyclic antidepressants, phenothiazines, vasopressor drugs, ergot-type oxytocic drugs, and beta-blockers. Tell your doctor all medications and supplements you use.

Xylocaine Dental Injection During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Xylocaine DENTAL Solutions; it is unknown if it will affect a fetus. It is unknown if Xylocaine DENTAL Solution passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Xylocaine DENTAL Solutions (lidocaine HCl 2% and epinephrine 1:50,000 injection) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Xylocaine DENTAL Injection Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregiver right away if you have:

  • twitching, tremors, seizure (convulsions);
  • a light-headed feeling, like you might pass out;
  • slow heart rate, weak pulse, weak or shallow breathing;
  • sudden feeling of heat, cold, or numbness;
  • muscle stiffness and pain;
  • weak or shallow breathing;
  • blue appearance of the skin; or
  • severe anxiety, unusual fear or uneasy feeling.

Common side effects may include:

  • drowsiness, dizziness;
  • nausea, vomiting;
  • feeling hot or cold;
  • confusion, ringing in your ears, blurred vision, double vision; or
  • numbness in places where the medicine is accidentally applied.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Xylocaine DENTAL Injection (lidocaine HCl and epinephrine)


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Xylocaine DENTAL Injection Professional Information


Adverse experiences following the administration of lidocaine are similar in nature to those observed with other amide-type local anesthetic agents. These adverse experiences are, in general, dose-related and may result from high plasma levels (which may be caused by excessive dosage, rapid absorption, unintended intravascular injection or slow metabolic degradation), injection technique, volume of injection, hypersensitivity, idiosyncrasy or diminished tolerance on the part of the patient. Serious adverse experiences are generally systemic in nature. The following types are those most commonly reported :

Central Nervous System

CNS manifestations are excitatory and/or depressant and may be characterized by lightheadedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, vomiting, sensations of heat, cold or numbness, twitching, tremors, convulsions, unconsciousness, respiratory depression and arrest. The excitatory manifestations may be very brief or may not occur at all, in which case the first manifestation of toxicity may be drowsiness merging into unconsciousness and respiratory arrest.

Drowsiness following the administration of lidocaine is usually an early sign of a high blood level of the drug and may occur as a consequence of rapid absorption.

Cardiovascular System

Cardiovascular manifestations in response to lidocaine are usually depressant and are characterized by bradycardia, hypotension, and cardiovascular collapse, which may lead to cardiac arrest. In addition, the beta-adrenergic receptor-stimulating action of epinephrine may lead to excitatory cardiovascular responses, such as tachycardia, palpitations, and hypertension.

Signs and symptoms of depressed cardiovascular function may commonly result from a vasovagal reaction, particularly if the patient is in an upright position. Less commonly, they may result from a direct effect of the drug. Failure to recognize the premonitory signs such as sweating, a feeling of faintness, changes in pulse or sensorium may result in progressive cerebral hypoxia and seizure or serious cardiovascular catastrophe. Management consists of placing the patient in the recumbent position and ventilation with oxygen. Supportive treatment of circulatory depression may require the administration of intravenous fluids and, when appropriate, a vasopressor (e.g, ephedrine) as directed by the clinical situation.

Allergic Reactions

Allergic reactions are characterized by cutaneous lesions, urticaria, edema , anaphylactoid reactions , or dyspnea due to bronchoconstriction. Allergic reactions as a result of sensitivity to lidocaine are extremely rare and, if they occur, should be managed by conventional means. The detection of sensitivity by skin testing is of doubtful value.

Neurologic Reactions

The incidences of adverse reactions (e.g., persistent neurologic deficit) associated with the use of local anesthetics may be related to the technique employed, the total dose of local anesthetic administered, the particular drug used, the route of administration, and the physical condition of the patient.

Persistent paresthesias of the lips, tongue, and oral tissues have been reported with the use of lidocaine, with slow, incomplete, or no recovery. These post-marketing events have been reported chiefly following nerve blocks in the mandible and have involved the trigeminal nerve and its branches.

Read the entire FDA prescribing information for Xylocaine DENTAL Injection (lidocaine HCl and epinephrine)

© Xylocaine DENTAL Injection Patient Information is supplied by Cerner Multum, Inc. and Xylocaine DENTAL Injection Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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