Xylocaine

Last updated on RxList: 2/24/2021
Xylocaine Side Effects Center

What Is Xylocaine?

Xylocaine (lidocaine HCl) Injection is a local anesthetic used for local or regional anesthesia. Xylocaine is available in generic form.

What Are Side Effects of Xylocaine?

Common side effects of Xylocaine include:

  • nausea,
  • dizziness,
  • numbness in places where the medicine is accidentally applied, or
  • bruising, redness, itching, or swelling where the medication was injected.

Unlikely but serious side effects of Xylocaine include:

Dosage for Xylocaine

For normal healthy adults, the individual maximum recommended dose of Xylocaine should not exceed 4.5 mg/kg (2 mg/lb) of body weight, and in general it is recommended that the maximum total dose does not exceed 300 mg.

What Drugs, Substances, or Supplements Interact with Xylocaine?

Xylocaine may interact with monoamine oxidase inhibitors (MAOIs), antidepressants, phenothiazines, butyrophenones, vasopressor drugs, ergot-type oxytocic drugs, or drugs that can cause drowsiness such as medicine for sleep, sedatives, tranquilizers, anti-anxiety drugs, narcotics, psychiatric medicines, anti-seizure drugs, muscle relaxants, or antihistamines. Tell your doctor all medications and supplements you use.

Xylocaine During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant before using Xylocaine. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Xylocaine (lidocaine HCl) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Xylocaine Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregiver right away if you have:

  • twitching, tremors, seizure (convulsions);
  • a light-headed feeling, like you might pass out;
  • slow heart rate, weak pulse, weak or shallow breathing;
  • sudden feeling of heat, cold, or numbness;
  • muscle stiffness and pain;
  • weak or shallow breathing;
  • blue appearance of the skin; or
  • severe anxiety, unusual fear or uneasy feeling.

Common side effects may include:

  • drowsiness, dizziness;
  • nausea, vomiting;
  • feeling hot or cold;
  • confusion, ringing in your ears, blurred vision, double vision; or
  • numbness in places where the medicine is accidentally applied.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Xylocaine (Lidocaine)

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Xylocaine Professional Information

SIDE EFFECTS

Adverse experiences following the administration of lidocaine are similar in nature to those observed with other amide local anesthetic agents. These adverse experiences are, in general, dose-related and may result from high plasma levels caused by excessive dosage or rapid absorption, or may result from a hypersensitivity, idiosyncrasy, or diminished tolerance on the part of the patient. Serious adverse experiences are generally systemic in nature. The following types are those most commonly reported:

There have been rare reports of endotracheal tube occlusion associated with the presence of dried jelly residue in the inner lumen of the tube (see WARNINGS and DOSAGE AND ADMINISTRATION).

Central Nervous System

CNS manifestations are excitatory and/or depressant and may be characterized by lightheadedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, vomiting, sensations of heat, cold or numbness, twitching, tremors, convulsions, unconsciousness, respiratory depression, and arrest. The excitatory manifestations may be very brief or may not occur at all, in which case the first manifestation of toxicity may be drowsiness merging into unconsciousness and respiratory arrest.

Drowsiness following the administration of lidocaine is usually an early sign of a high blood level of the drug and may occur as a consequence of rapid absorption.

Cardiovascular System

Cardiovascular manifestations are usually depressant and are characterized by bradycardia, hypotension, and cardiovascular collapse, which may lead to cardiac arrest.

Allergic

Allergic reactions are characterized by cutaneous lesions, urticaria, edema, or anaphylactoid reactions. Allergic reactions may occur as a result of sensitivity either to the local anesthetic agent or to other components in the formulation. Allergic reactions as a result of sensitivity to lidocaine are extremely rare and, if they occur, should be managed by conventional means. The detection of sensitivity by skin testing is of doubtful value.

Read the entire FDA prescribing information for Xylocaine (Lidocaine)

© Xylocaine Patient Information is supplied by Cerner Multum, Inc. and Xylocaine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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